天津医药

天津医药 ›› 2019, Vol. 47 ›› Issue (10): 1072-1075.doi: 10.11958/20190128

• 临床研究 • 上一篇    下一篇

Randall斑泌尿系结石患者的代谢评估

张一帆，许长宝△，万优，王曦堃，周德志，冀明阳，王友铭   

  1. 郑州大学第二附属医院泌尿外科（邮编450014）
  • 收稿日期:2019-01-16 修回日期:2019-07-02 出版日期:2019-10-15 发布日期:2019-11-11
  • 通讯作者: 张一帆 E-mail:zyfzwd@126.com
  • 基金资助:
     

Metabolic evaluation for patients with Randall’s plaque urolithiasis

ZHANG Yi-fan, XU Chang-bao△, WAN You, WANG Xi-kun, ZHOU De-zhi, JI Ming-yang, WANG You-ming   

  1. Department of Urology, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450014, China
  • Received:2019-01-16 Revised:2019-07-02 Published:2019-10-15 Online:2019-11-11
  • Contact: Yi-Fan ZHANG E-mail:zyfzwd@126.com
  • Supported by:
     

PDF (PC)

3569

摘要： 摘要：目的 通过对Randall斑结石患者进行24 h尿代谢分析，探讨Randall斑患者的结石危险因素及机制。方 法 收集 2017 年 10 月—2018 年 10 月于我院接受住院治疗的泌尿系结石患者 50 例，其中有 Randall 斑结石患者 （Randall斑组）30例，无Randall斑结石患者（无Randall斑组）20例，另择我院同期健康体检者30例为对照组。收集 患者24 h尿液进行尿液成分分析，对于排出的结石采用红外光谱分析仪检测结石成分。结果 Randall斑组中结石 的大小、位置、所在侧和结石成分与无Randall斑组差异均无统计学意义。与对照组相比，无Randall斑组24 h尿液中 枸橼酸含量降低，草酸、磷酸含量升高（P＜0.05），Randall斑组24 h尿液中枸橼酸含量降低，草酸、磷酸、钠、钙含量升 高（P＜0.05）。与无 Randall 斑组相比，Randall 斑组 24 h 尿液中枸橼酸含量降低，草酸、磷酸、钠、钙含量升高（P＜ 0.05）。结论 Randall 斑患者 24 h 尿液中高钠、钙、草酸、磷酸和低枸橼酸对结石的发生发展有重要影响，应限制 Randall斑的泌尿系结石患者草酸、钠、钙、磷酸等的摄入并酌情补充枸橼酸。

关键词: Randall斑, 泌尿系结石, 24 h尿液, 危险因素

Abstract: Abstract：Objective To investigate the stone risk factors in patients with Randall’s plaques by analyzing the 24-h urinary metabolic analysis. Methods From October 2017 to October 2018, 30 patients with Randall’s plaques, 20 patients with no - Randall’s plaques and 30 healthy people were collected, and 24-h urine samples were analyzed. The stone components were analyzed by infrared spectroscopy. Results There were no significant differences in size, location, side and composition of the stones between Randall’s plaque group and no-Randall’s plaque. The content of citric acid decreased, while the contents of oxalic acid and phosphoric acid increased in Randall’s plaque group than those of control group (P＜0.05). In Randall plaque group, the content of citric acid in 24-h urine decreased, while the contents of oxalic acid, phosphoric acid, sodium and calcium increased (P＜0.05). Compared with no-Randall’s plaque group, the contents of citric acid in 24 h urine decreased, and the contents of oxalic acid, phosphoric acid, sodium and calcium increased in Randall plaque group (P＜0.05). Conclusion The high sodium, calcium, oxalic acid, phosphoric acid and low citric acid in 24-hour urine of patients with Randall’s plaques have important effects on the occurrence and development of urolithiasis. The intake of oxalic acid, sodium, calcium and phosphoric acid should be limited and citric acid should be supplemented in patients with Randall’s plaque urolithiasis.

Key words: Randall’s plaque, urinary stone, 24-h urine, risk factors

中图分类号: