天津医药

天津医药 ›› 2020, Vol. 48 ›› Issue (9): 898-902.doi: 10.11958/20200625

• 综述 • 上一篇    下一篇

Tim-3调控巨噬细胞极化在类风湿性关节炎中的研究进展

钟玉梅，陈洋，罗小超，周海燕   

  1. 成都中医药大学针灸推拿学院（邮编610075）
  • 收稿日期:2020-03-23 修回日期:2020-06-24 出版日期:2020-09-15 发布日期:2020-09-22
  • 通讯作者: 钟玉梅 E-mail:704755938@qq.com
  • 基金资助:
    国家重点研发计划资助项目（2019YFC1709001）；国家自然科学基金面上资助项目（81973959，81674068）；四川省中医药管理局基础研究项目（2018JC007）

Research progress of Tim-3 regulating the polarization of macrophage in rheumatoid arthritis

ZHONG Yu-mei, CHEN Yang, LUO Xiao-chao, ZHOU Hai-yan   

  1. School of Acupuncture-Moxibustion and Tuina, Chengdu University of TCM, Chengdu 610075, China
  • Received:2020-03-23 Revised:2020-06-24 Published:2020-09-15 Online:2020-09-22
  • Contact: Yu-mei Zhong E-mail:704755938@qq.com

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摘要： 摘要：类风湿性关节炎（RA）是由自身免疫功能紊乱导致的慢性难治性疾病，T细胞被持续活化并长期处于高反应的状态是其免疫反应的重要环节。T细胞免疫球蛋白黏蛋白分子-3（Tim-3）是在免疫系统的各种类型细胞上表达的表面分子，其信号传导可以增强或抑制巨噬细胞的免疫反应。越来越多的研究表明，Tim-3在免疫系统中具有关键作用，可调控巨噬细胞极化，促进各种细胞内信号传导和免疫反应，在RA病理过程中具有重要意义。本文综述近年来关于Tim-3调控巨噬细胞极化在RA中的相关研究进展，为治疗RA提供新的思路。

关键词: 关节炎, 类风湿；巨噬细胞；Tim-3；巨噬细胞极化

Abstract: Abstract: Rheumatoid arthritis (RA) is a chronic and refractory disease caused by autoimmune dysfunction. The continuous activation and the status of long-term high response of T cells are important links of its immune response. T cell immunoglobulin and mucin-domain-containing molecule-3 (Tim-3) is a surface molecule expressed on various cell types of immune system, and its signal transduction can enhance or inhibit the immune response of macrophages. A large number of studies have indicated that Tim-3 plays an important role in the immune system, such as regulating the polarization of macrophage, promoting the transduction of various intracellular signal and immune responses and playing a key role in the pathogenesis of RA. Therefore, the paper reviews the relevant research progress on Tim-3 regulating the polarization of macrophage in RA in recent years and provides new ideas for deepening the treatment of RA.

Key words: arthritis, rheumatoid, macrophages, Tim-3, macrophage polarization

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