天津医药

天津医药 ›› 2020, Vol. 48 ›› Issue (9): 886-890.doi: 10.11958/20200853

• 药物临床观察 • 上一篇    下一篇

滋肾育癸汤对卵巢功能不全患者抗苗勒管激素、雌二醇、卵泡刺激素的影响#br#

池雷，张秦△   

  1. 南京中医药大学附属医院妇科（邮编210029）
  • 收稿日期:2020-04-07 修回日期:2020-05-30 出版日期:2020-09-15 发布日期:2020-09-22
  • 通讯作者: 池雷 E-mail:chileidt@sina.com

The effects of Zishen Yugui decoction on serum anti-Mullerian hormone, estradiol and follicle stimulating hormone in patients with premature ovarian insufficiency

CHI Lei， ZHANG Qin△   

  1. Department of Gynecology, the Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China
  • Received:2020-04-07 Revised:2020-05-30 Published:2020-09-15 Online:2020-09-22

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摘要： 摘要：目的　研究滋肾育癸汤对卵巢功能不全（POI）患者血清抗苗勒管激素（AMH）、雌二醇（E2）、卵泡刺激素（FSH）的影响。方法　157例POI患者随机分为中药（滋肾育癸汤）治疗组51例、芬吗通治疗组54例和联合治疗（芬吗通+滋肾育癸汤）组52例，比较3组治疗总有效率及治疗前、治疗第4周、治疗第12周血清AMH、E2、FSH水平，比较3组治疗前、治疗后4周月经情况及妊娠率、内膜厚度、卵巢体积、基础窦卵泡数、卵巢最大血流速度（PSV）、卵巢阻力指数（RI），记录不良反应发生率。结果　联合治疗组治疗总有效率高于中药治疗组和芬吗通治疗组（P＜0.05）；治疗第4周、第12周联合治疗组AMH、E2水平高于中药治疗组和芬吗通治疗组，而FSH水平低于中药治疗组和芬吗通组（P＜0.05）；治疗后4周，联合治疗组较中药治疗组和芬吗通治疗组月经周期时长、经期时长延长，月经量增多（P＜0.05），联合治疗组妊娠率最高（P＜0.05）；治疗后联合治疗组内膜厚度较中药治疗组和芬吗通治疗组薄，联合治疗组卵巢体积、基础窦卵泡数、PSV较中药治疗组和芬吗通治疗组增加，联合治疗组RI最小（P＜0.05）；3组均未见明显不良反应。结论　滋肾育癸汤联合芬吗通可有效改善POI患者月经紊乱、阴道超声参数，提高妊娠率，有效调节血清AMH、E2、FSH水平，安全性可靠。

关键词: 原发性卵巢功能不全, 雌二醇, 卵泡刺激素, 抗苗勒管激素, 滋肾育癸汤

Abstract: Abstract: Objective　To study the impact of Zishen Yugui decoction on serum anti-Müllerian hormone (AMH), estradiol (E2) and follicle stimulating hormone (FSH) in patients with premature ovarian insufficiency (POI). Methods　A total of 157 patients with POI were randomized into 3 groups: the Chinese medicine group (51 cases treated with Zishen Yugui decoction), the Femoston group (54 cases treated with Femoston) and the combined treatment group (52 cases treated with both Femoston and Chinese medicine). The total efficiency was analyzed compared between the 3 groups.The serum levels of AMH, E2 and FSH before and after treatment were compared between the three groups.Besides, the situation of menstruation, pregnancy rate, endometrial thickness, ovarian volume, antral follicle count, ovarian peak systolic velocity (PSV) and RI before treatment and 4 weeks after treatment were compared between the 3 groups. Meanwhile, the incidence of adverse reaction was recorded. Results　Compared with the Chinese medicine group and the Femoston group, the total efficiency was higher in the combined treatment group (P＜0.05).In the 4th and 12th week of treatment, the serum levels of AMH and E2 were higher in the combined treatment group than those of Chinese medicine group and the Femoston group, and the FSH level was lower in the combined treatment group (P＜0.05). At 4-week treatment, the menstrual cycle, menstrual period and menstrual volume were longer/more in the combined treatment group than those of Chinese medicine group and the Femoston group (P＜0.05), and the pregnancy rate was higher in the combined treatment group (P＜0.05). Compared with the Chinese medicine group and the Femoston group, the endometrial thickness and resistance index (RI) were smaller, and the ovarian volume, antral follicle count and ovarian PSV were larger in the combined treatment group (P＜0.05). No significant adverse reactions were found in the 3 groups.Conclusion　Menstrual disorders, vaginal ultrasound parameters, pregnancy rate, and serum levels of AMH, E2 and FSH can be effectively improved through treatment with Zishen Yugui decoction in patients with POI. The treatment method is safe and reliable.

Key words: primary ovarian insufficiency, estradiol, follicle stimulating hormone, anti-mullerian hormone, ZishenYugui decoction