天津医药

天津医药 ›› 2017, Vol. 45 ›› Issue (6): 596-600.doi: 10.11958/20170184

• 临床研究 • 上一篇    下一篇

血清 FSH、LH、PRL 与浆液性卵巢癌临床 病理特征及预后的关系

崔蕾，郭飞，闫晔，潘明霞，董羊羊，薛凤霞△   

  1. 天津医科大学总医院妇产科（邮编 300052）
  • 收稿日期:2017-02-16 修回日期:2017-04-19 出版日期:2017-06-15 发布日期:2017-07-05
  • 通讯作者: △通讯作者 E-mail: fengxiaxue1962@163.com E-mail:a1234_1982@163.com
  • 作者简介:崔蕾（1991），女，硕士在读，主要从事妇科肿瘤方面研究
  • 基金资助:
    国家自然科学基金青年项目（81602292）

The relationship of serum levels of FSH, LH and PRL and clinicopathological features and prognosis in patients with serous ovarian cancer

CUI Lei, GUO Fei, YAN Ye, PAN Ming-xia, DONG Yang-yang, XUE Feng-xia△   

  1. Department of Obstetrics and Gynecology, Tianjin Medical University General Hospital, Tianjin 300052, China
  • Received:2017-02-16 Revised:2017-04-19 Published:2017-06-15 Online:2017-07-05
  • Contact: △Corresponding Author E-mail: fengxiaxue1962@163.com E-mail:a1234_1982@163.com

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摘要： 目的 探讨血清卵泡刺激素（FSH）、黄体生成素（LH）、催乳素（PRL）与浆液性卵巢癌临床病理特征及预后 的关系。方法 选择 2000 年 1 月—2015 年 12 月在天津医科大学总医院妇产科住院治疗的浆液性卵巢癌患者 73 例。采用 Mann-Whitney U 检验分析患者血清 FSH、LH、PRL 与临床病理特征的关系，采用 Kaplan-Meier （K-M）分析 不同临床病理特征患者生存率差异，多因素 COX 比例风险回归模型分析浆液性卵巢癌患者预后的影响因素。结 果 年龄>50 岁组血清 FSH、LH 水平显著高于年龄≤50 岁组，绝经组血清 FSH、LH 水平显著高于未绝经组（均 P< 0.05），其他不同临床病理特征分组患者间血清 FSH、LH 水平差异无统计学意义；不同临床病理特征分组患者间血清 PRL 水平差异均无统计学意义。单因素分析显示，血清 FSH 水平高（>40.13 IU/L）、血清 PRL 水平高（>14.96 μg/L）、 FIGO 分期（Ⅲ+Ⅳ）的患者预后差（均 P<0.05）；血清 LH 水平与患者预后无关（P＞0.05）。COX 多因素回归分析显 示，血清 PRL>14.96 μg/L 是影响浆液性卵巢癌预后的危险因素[HR（95%CI）为 3.530（1.180～10.557），P=0.024]。结 论 绝经后妇女血清中 FSH、LH 水平较绝经前显著升高，PRL 与浆液性卵巢癌患者预后有关。

关键词: 卵巢肿瘤, 卵泡刺激素, 促黄体激素, 催乳素, 预后, 浆液性卵巢癌

Abstract: Objective To investigate the relationship between serum follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL) and clinicopathological features and prognosis of serous ovarian cancer retrospectively. Methods A total of 73 patients with serous ovarian cancer treated in the Department of Obstetrics and Gynecology of Tianjin Medical University General Hospital from January 2000 to December 2015 were included in this study. The relationship between serum FSH, LH, PRL and clinicopathological features was analyzed by Mann- Whitney U method. Kaplan-Meier (K-M) method was used to analyze survival rates of patients with different clinical features. Multivariate Cox proportional hazards regression analysis was used to analyze prognostic factors of serous ovarian cancer patients. Results The mean concentrations of serum FSH and LH were significantly higher in the >50 year-old group than those in the <50 year-old group (P＜0.05). The mean concentrations of FSH and LH were significantly higher in menopause group than those in non - menopause group (P＜0.05). There were no significant differences in serum levels of FSH and LH in patients with other different clinicopathological features (P＞0.05). There was no significant correlation between serum PRL concentration and clinicopathological features (P＞0.05). Analysis results showed that poor prognosis of patients was related with high serum levels of FSH (>40.13 IU/L), PRL (>14.96 μg/L) and FIGO stage ( Ⅲ + Ⅳ) (P＜0.05). There was no significant correlation between serum LH concentration and prognosis (P＞0.05). COX regression analysis showed that the serum PRL> 14.96 μg/L was risk factor for prognosis of serous ovarian cancer [HR（95% CI）: 3.530（1.180- 10.557)，P=0.024]. Conclusion The serum levels of FSH and LH are significantly increased in postmenopausal women than those in menopause women. The serum level of PRL is correlated with the prognosis of serous ovarian cancer.

Key words: ovarian neoplasms, follicle stimulating hormone, luteinizing hormone, prolactin, prognosis, serous ovarian cancer