天津医药

天津医药 ›› 2021, Vol. 49 ›› Issue (1): 54-58.doi: 10.11958/20202213

• 临床研究 • 上一篇    下一篇

中青年和老年冠心病患者LDL不同亚型与AIP的相关性分析#br#

赵洁，李淑英，张英，单伟超，张皓然，韩冷，丁振江△   

  1. 承德医学院附属医院心脏内科，承德市心血管研究所（邮编067000）
  • 收稿日期:2020-08-03 修回日期:2020-11-16 出版日期:2021-01-15 发布日期:2021-01-15
  • 通讯作者: 丁振江 E-mail:15633142632@163.com
  • 基金资助:
    河北省政府资助专科带头人项目;承德市科技发展项目

Correlation analysis of different subtypes of LDL and AIP in young and middle-aged and elderly patients with coronary heart disease

ZHAO Jie, LI Shu-ying, ZHANG Ying, SHAN Wei-chao, ZHANG Hao-ran, HAN Leng, DING Zhen-jiang△   

  1. Department of Cardiology, the Affiliated Hospital of Chengde Medical College; Chengde Cardiovascular Institute, Chengde 067000, China
  • Received:2020-08-03 Revised:2020-11-16 Published:2021-01-15 Online:2021-01-15

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摘要： 目的：探讨低密度脂蛋白（low density lipoprotein,LDL）不同亚型与不同年龄组冠状动脉心脏病（coronary artery disease, CAD）患病的相关性及差异。方法：连续入选2018年9月至2019年11月承德医学院附属医院心内科住院，通过冠状动脉造影术诊断冠状动脉心脏病患者256例作为本研究对象,分中青年组（n=150，年龄<65岁）和老年CAD组(n=106，年龄≥65岁)。用凝胶电泳法对LDL各亚型进行定量分析。采用spearmen秩相关分析LDL各亚型与AIP的相关性，用多重线性回归分析各LDL亚型作为AIP的独立预测因子。结果：AIP中位数中青年CAD组大于老年CAD组（P<0.05）。大而轻LDL及其亚型LDL1、LDL2，中间LDL的亚型LDL4和小而密LDL及其亚型LDL5与AIP的相关性老年组大于中青年组（均P<0.05）。大而轻LDL及其亚型LDL1、LDL2是CAD患者AIP的独立负性预测因子，中间LDL亚型中LDL4和小而密LDL及其亚型LDL5是CAD患者的AIP独立正性预测因子（均P<0.05）。结论：LDL不同亚型与中青年和老年人群CAD患病的相关性不同，预测患CAD的风险存在差异，尤其是老年患者更加显著。

关键词: 脂蛋白类, LDL；冠心病；低密度脂蛋白亚型；血浆致动脉粥样硬化指数

Abstract: Objective: The aim of the study was to explore the association of different （low density lipoprotein,LDL）subtypes with coronary artery disease (CAD) in different age groups. Methods: A total of 256 subjects with CAD who were diagnosed by coronary angiography and hospitalized in the department of Cardiology, Affiliated Hospital of Chengde Medical College from September 2018 to November 2019 were continuously enrolled in this study, and all of them were divided into the young and middle-aged CAD group (n = 150, age <65 years) and elderly CAD group (n = 106, age ≥65 years). Quantitative analysis of LDL subtypes were performed by gel electrophoresis. Spearmen rank correlation was used to analyze the correlation among LDL subtypes and AIP. The multiple linear regression analysis was used to analyze each LDL subtype as an independent predictor of AIP. Results: The median of AIP in young CAD group was higher than the elderly CAD group (P <0.05). The correlation of the large-buoyant LDL and its subtypes LDL1, LDL2, the intermediate LDL subtype LDL4 and the small-dense LDL and its subtype LDL5 with AIP was greater in the elderly group (all P <0.05). large-buoyant LDL and its subtypes LDL1, LDL2 are independent negative predictors of AIP in CAD patients, intermediate LDL subtypes LDL4 and small-dense LDL and its subtype LDL5 are independent positive predictors of AIP in CAD patients (all P <0.05). Conclusion: The correlations of different LDL subtypes with CAD prevalence in young and middle-aged and elderly-aged populations were different, and the risk of predicting CAD were also different, especially in elderly patients.

Key words: lipoproteins, LDL, coronary disease, low density lipoprotein subtype, atherosclerotic index of plasma