天津医药

天津医药 ›› 2021, Vol. 49 ›› Issue (10): 1107-1111.doi: 10.11958/20210743

• 综述 • 上一篇    下一篇

骨形态发生蛋白-7参与糖尿病肾病发病机制的研究进展

张颖超，米焱，王彩丽   

  1. 内蒙古科技大学包头医学院第一附属医院肾内科（邮编014010）
  • 收稿日期:2021-03-29 修回日期:2021-04-28 出版日期:2021-10-15 发布日期:2021-10-15
  • 通讯作者: 王彩丽 E-mail:wangcail213@163.com
  • 基金资助:
    骨形态发生蛋白7修饰的骨髓间充质干细胞对糖尿病肾病纤维化的修复及相关机制

Advances of bone morphogenetic protein -7 in the pathogenesis of diabetic nephropathy

ZHANG Ying-chao, MI Yan, WANG Cai-li #br#   

  1. Department of Nephrology, the First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and
    Technology, Baotou 014010, China
  • Received:2021-03-29 Revised:2021-04-28 Published:2021-10-15 Online:2021-10-15

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摘要： 糖尿病肾病是危害糖尿病患者健康的严重微血管并发症，以微量白蛋白尿、肾小球基底膜增厚、细胞外基 质沉积、肾小球肥大和系膜扩张为主要特征。在糖尿病肾病发生、发展过程中，骨形态发生蛋白（BMP）-7作为转化 生长因子（TGF）-β超家族的一员发挥多种生物学功能，参与肾小球系膜细胞扩张度、足细胞凋亡、肾小管损伤以及 肾脏纤维化的调节。围绕BMP-7与TGF-β/Smads信号通路、PI3K/Akt信号通路以及间充质干细胞在糖尿病肾病中 的作用机制进行论述，以期为相关研究提供参考。

关键词: 骨形态发生蛋白质7, 糖尿病肾病, 转化生长因子β, Smad蛋白质类, 磷酸肌醇3-激酶类, 原癌基因蛋白质c-akt, 间充质基质细胞

Abstract: Diabetic nephropathy is a serious microvascular complication that endangers the health of diabetic patients. It is mainly characterized by microalbuminuria, glomerular basement membrane thickening, extracellular matrix deposition, glomerular hypertrophy and mesangial membrane dilatation. In the development of this disease, bone morphogenetic protein -7 (BMP-7), as a member of the transforming growth factor β (TGF-β) superfamily, plays a variety of biological functions. It is involved in the regulation of renal mesangial cell dilation, podocyte apoptosis, renal tubule injury and renal fibrosis. In this paper, we discussed the mechanism of BMP-7 and TGF- β/Smads signaling pathway, PI3K/Akt signaling pathway and mesenchymal stem cells in diabetic nephropathy, in order to provide reference for the related research.

Key words: bone morphogenetic protein 7, diabetic nephropathies, transforming growth factor beta, Smad proteins,
phosphatidylinositol 3-kinases, proto-oncogene proteins c-akt, mesenchymal stem cells