天津医药

天津医药 ›› 2022, Vol. 50 ›› Issue (7): 739-743.doi: 10.11958/20212423

• 临床研究 • 上一篇    下一篇

NSTE-ACS合并2型糖尿病患者非罪犯病变斑块负荷的研究

陈蒙，张颖，刘玉洁   

  1. 1天津医科大学胸科临床学院（邮编300222）；2天津市胸科医院心内四科
  • 收稿日期:2021-10-27 修回日期:2022-03-18 出版日期:2022-07-15 发布日期:2022-07-15
  • 基金资助:
    天津卫生健康委员会中医药重点领域科研项目（2019005）

Study on the load of non-criminal plaques in NSTE-ACS patients with type 2 diabetes

CHEN Meng, ZHANG Ying, LIU Yujie   

  1. 1 Thoracic Clinical College, Tianjin Medical University, Tianjin 300222, China; 2 the Forth Department of Cardiology, Tianjin Chest Hospital
  • Received:2021-10-27 Revised:2022-03-18 Published:2022-07-15 Online:2022-07-15

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摘要： 目的　应用冠状动脉CT血管成像（CTA）量化评估非ST段抬高型急性冠脉综合征（NSTE-ACS）合并2型糖尿病（T2DM）患者非罪犯病变（NCL）的斑块负荷。方法　纳入行冠脉CTA检查的NSTE-ACS患者112例，根据是否合并T2DM将患者分为试验组（58例）和对照组（54例），均已成功对2组患者冠状动脉造影（CAG）显示的罪犯病变（CL）行冠状动脉介入治疗，结合半自动斑块量化软件评估2组患者NCL的斑块负荷。结果　试验组患者NCL斑块的非钙化斑块体积、低密度非钙化斑块体积、总斑块体积、非钙化斑块负荷、低密度非钙化斑块负荷及总斑块负荷显著大于对照组（P＜0.01）。2组患者的NCL斑块的钙化斑块体积、钙化斑块负荷和RI比较差异无统计学意义（P＞0.05）。空腹血糖与NCL斑块的非钙化斑块体积（rs=0.472）、低密度非钙化斑块体积（rs=0.370）、总斑块体积（rs=0.522）、非钙化斑块负荷（rs=0.502）、低密度非钙化斑块负荷（rs=0.536）、总斑块负荷（rs=0.486）呈正相关。结论　NSTE-ACS合并T2DM患者的NCL斑块负荷较大，且血糖会影响斑块体积和负荷。

关键词: 急性冠状动脉综合征, 糖尿病, 2型, 冠脉CT血管成像, 非罪犯病变, 罪犯病变, 斑块负荷

Abstract: Objective　To quantitatively evaluate the plaque load of non-criminal lesions (NCL) by coronary CT angiography (CTA) in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS) complicated with type 2 diabetes mellitus (T2DM). Methods　A total of 112 patients with NSTE-ACS who underwent coronary CTA examination were divided into the experimental group (58 cases) and the control group (54 cases) according to whether they were complicated with T2DM. Patients in both groups were successfully treated with PCI for criminal lesions (CL) shown by coronary angiography (CAG). Semi-automatic plaque quantification software was used to assess NCL plaque load in the two groups. Results　The non-calcified plaque volume, low-density non-calcified plaque volume, total plaque volume, non-calcified plaque load, low-density non-calcified plaque load and total plaque load of NCL plaques were significantly higher in the experimental group than those in the control group (P＜0.01). There were no significant differences in NCL plaque volume, calcified plaque load and RI between the two groups (P＞0.05). There was a positive correlation between blood glucose and NCL plaque non-calcified plaque volume (rs=0.472), low-density non-calcified plaque volume (rs=0.370), total plaque volume (rs=0.522), non-calcified plaque load (rs=0.502), low density non-calcified plaque load (rs=0.536) and total plaque load (rs=0.486). Conclusion　Patients with NSTE-ACS combined with T2DM have a large NCL plaque load, and blood glucose affects the plaque volume and load.

Key words: acute coronary syndrome, diabetes mellitus, type 2, coronary CT angiography, non-criminal lesion, criminal lesion, plaque load