SIRT1在糖尿病心肌病发病中的研究进展

doi:10.11958/20231289

天津医药 ›› 2024, Vol. 52 ›› Issue (4): 443-448.doi: 10.11958/20231289

• 综述 • 上一篇

SIRT1在糖尿病心肌病发病中的研究进展

解有成¹^,²^,³^,⁴(), 王菲², 徐进², 于晓辉²^,^△()

1 甘肃中医药大学第一临床医学院（邮编730000）
2 中国人民解放军联勤保障部队第九四〇医院内科
3 中国人民解放军联勤保障部队第九四〇医院基础医学实验室
4 甘肃省干细胞与基因药物重点实验室

收稿日期:2023-08-28 修回日期:2023-10-20 出版日期:2024-04-15 发布日期:2024-04-19
通讯作者: ^△E-mail：yuxiaohui528@126.com
作者简介:解有成（1996），男，硕士在读，主要从事SIRT1及糖尿病心肌病的基础研究。E-mail：229627374@qq.com
基金资助:
甘肃省自然科学基金项目(21JR1RA181);甘肃省卫生健康行业健康计划项目(GSWSKY2022-49)

Research progress of SIRT1 in the pathogenesis of diabetic cardiomyopathy

XIE Youcheng¹^,²^,³^,⁴(), WANG Fei², XU Jin², YU Xiaohui²^,^△()

1 The First Clinical College of Medicine, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China
2 Department of Internal Medicine, 940th Hospital of the PLA Joint Logistic Support Force
3 Laboratory of Basic Medicine, 940th Hospital of the PLA Joint Logistic Support Force
4 Gansu Provincial Key Laboratory of Stem Cell and Gene Medicine

Received:2023-08-28 Revised:2023-10-20 Published:2024-04-15 Online:2024-04-19
Contact: ^△E-mail：yuxiaohui528@126.com

解有成, 王菲, 徐进, 于晓辉. SIRT1在糖尿病心肌病发病中的研究进展[J]. 天津医药, 2024, 52(4): 443-448.

XIE Youcheng, WANG Fei, XU Jin, YU Xiaohui. Research progress of SIRT1 in the pathogenesis of diabetic cardiomyopathy[J]. Tianjin Medical Journal, 2024, 52(4): 443-448.

摘要/Abstract

摘要：

糖尿病心肌病（DCM）是糖尿病患者的一种严重的心血管并发症。去乙酰化酶沉默信息调节因子2同源物1（SIRT1）作为机体重要的细胞内调控蛋白，在许多生物过程中发挥重要作用，包括减轻心肌细胞氧化应激、维持心肌线粒体Ca²⁺稳态、降低心肌内质网应激、改善心肌线粒体功能障碍以及抑制机体肾素-血管紧张素-醛固酮系统的活化等，可能是DCM的潜在治疗靶点，靶向SIRT1进行深入研究能够为DCM的临床治疗提供新的理论依据。就SIRT1在DCM的发病机制中的具体作用及治疗策略进行综述。

关键词: 糖尿病, 糖尿病心肌病, 抗衰老酶1, 氧化性应激, 线粒体, 内质网应激, 肾素-血管紧张素-醛固酮系统

Abstract:

Diabetic cardiomyopathy (DCM) is one of the most serious cardiovascular complications in diabetic patients, and it is also the main cause of increased mortality in diabetic patients, which has become a major global public health problem. As an important intracellular regulatory protein in body, sirtuin 1 (SIRT1) plays an important role in many biological processes, including reducing oxidative stress in cardiomyocytes, maintaining Ca²⁺ homeostasis in myocardial mitochondria, reducing myocardial endoplasmic reticulum stress, improving myocardial mitochondrial dysfunction, and inhibiting the activation of renin-angiotensin-aldosterone system. SIRT1 may be a potential therapeutic target for DCM. Further research targeting SIRT1 can provide a new theoretical basis for the clinical treatment of DCM. This article reviews the specific role of SIRT1 in the pathogenesis and treatment strategies of DCM.

Key words: diabetes mellitus, diabetic cardiomyopathies, sirtuin 1, oxidative stress, mitochondria, endoplasmic reticulum stress, renin-angiotensin-aldosterone system

中图分类号:

R587.23

图/表 2

参考文献 40

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DCM分期	临床表现
1期	心脏舒张功能异常但射血分数正常^#
2期	心脏收缩和舒张功能共同受损
3期	收缩期和舒张期功能障碍伴有微血管疾病/非梗阻性冠状动脉粥样硬化症
4期	临床明显的心肌缺血/梗死引发心力衰竭

DCM分期	临床表现
1期	心脏舒张功能异常但射血分数正常^#
2期	心脏收缩和舒张功能共同受损
3期	收缩期和舒张期功能障碍伴有微血管疾病/非梗阻性冠状动脉粥样硬化症
4期	临床明显的心肌缺血/梗死引发心力衰竭

研究对象	NCT号	临床阶段	样本量	干预手段	研究目的	状态
DCM	04141475	未知	100	α-硫辛酸	治疗前后左室射血分数变化	未知
DCM	04083339	Ⅲ期	675	AT-001	心肺运动试验期间的峰值摄氧量	正在进行
DCM	05556005	Ⅱ期	60	曲美他嗪	与基线相比的变化3个月时的左心室功能	正在招募受试者
肥胖（DM/DM高风险）患者	01067209	未知	45	胃旁路手术	心脏功能，心肌脂肪沉积	正在进行
DCM	04200586	Ⅳ期	30	达格列净	心肌灌注储备指数变化	正在进行
EF降低的DM心力衰竭患者	04304560	Ⅱ期	60	达格列净	达格列净对2型糖尿病患者心肌病发病率和死亡率的影响	未知

研究对象	NCT号	临床阶段	样本量	干预手段	研究目的	状态
DCM	04141475	未知	100	α-硫辛酸	治疗前后左室射血分数变化	未知
DCM	04083339	Ⅲ期	675	AT-001	心肺运动试验期间的峰值摄氧量	正在进行
DCM	05556005	Ⅱ期	60	曲美他嗪	与基线相比的变化3个月时的左心室功能	正在招募受试者
肥胖（DM/DM高风险）患者	01067209	未知	45	胃旁路手术	心脏功能，心肌脂肪沉积	正在进行
DCM	04200586	Ⅳ期	30	达格列净	心肌灌注储备指数变化	正在进行
EF降低的DM心力衰竭患者	04304560	Ⅱ期	60	达格列净	达格列净对2型糖尿病患者心肌病发病率和死亡率的影响	未知

SIRT1在糖尿病心肌病发病中的研究进展

Research progress of SIRT1 in the pathogenesis of diabetic cardiomyopathy

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