天津医药

• 论著 •    

维甲酸受体α、β在卵巢组织中的表达及与卵巢肿瘤的关系

徐娟,曲芃芃   

  1. 天津市中心妇产科医院
  • 收稿日期:2009-08-31 修回日期:2010-02-02 出版日期:2010-08-15 发布日期:2010-08-15
  • 通讯作者: 徐娟

The expression and clinical significance of retinoic acid receptors αβ in ovarian tissues

  • Received:2009-08-31 Revised:2010-02-02 Published:2010-08-15 Online:2010-08-15

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摘要： 摘要 目的：探讨维甲酸受体αβ在正常卵巢及卵巢上皮性肿瘤中的表达及其与上皮性卵巢癌发生的关系。方法： 112例标本，其中正常卵巢组织20例、良性上皮性肿瘤20例、交界性上皮性肿瘤20例、上皮性卵巢癌52例。采用免疫组织化学法检测维甲酸受体αβ的表达。结果：卵巢癌、卵巢交界性肿瘤、良性肿瘤和正常组织中维甲酸受体α的阳性表达率分别为80.77%、50%、15%、20%，在肿瘤的不同病理分级、临床分期间表达差异有统计学意义；卵巢癌、卵巢交界性肿瘤、良性肿瘤和正常组织中维甲酸受体β76.92%、45%、30%、30%,在肿瘤的不同组织学类型、病理分级间表达差异有统计学意义。结论：RARαβ在卵巢癌组织中呈高表达，且可能与卵巢癌的发展有关，并为维甲酸治疗进展期卵巢癌提供依据。

关键词: 卵巢癌, 维甲酸受体, 免疫组织化学

Abstract: [Abstract] Objective：To explore the expression and clinical significance of retinoic acid receptors αβ in normal and abnormal ovarian epithelial cancer tissues．Methods：Expression of retinoic acid receptors was detected in 20 normaltissues, 20 benign tissues ,20 bordline tissues and 52 ovarian cancer tissues using immunohistochemistry．Results：The positive expression of retinoic acid receptorα in normal tissues , benignin tissues , bordline tissues and ovarian cancer patients were 80.77% 、50% 、15%、20% respectively,it has statistical significance in different pathological grade and FIGO stage. The positive expression of retinoic acid receptorβ in normal tissues , benignin tissues , bordline tissues and ovarian cancer patients were 76.92% 、45% 、30%、30% respectively．The expression of retinoic acid receptorβwere related to the histological type ,FIGO stage (P<0.05)． Conclusion：The expression of retinoic acid receptorαβwere higher in ovarian cancer ,and may be associated with ovarian carcinogenesis．

Key words: ovarian cancer, retinoic acid receptors, immunohistochemistry