天津医药

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DJ-1蛋白在卵巢癌患者血清中的表达及意义

刘辉1,王伟明2,蔡智慧2,左群1,刘金2,刘树芳1,董玉平1,鲁晓芳1   

  1. 1. 河北大学公共卫生学院
    2. 河北大学附属医院
  • 收稿日期:2014-03-14 修回日期:2014-04-04 出版日期:2014-09-15 发布日期:2014-09-15
  • 通讯作者: 刘辉

Expression and Clinic Significance of Serum DJ-1 in Ovarian Cancer

LIU Hui 1,WANG Weiming 2,CAI Zhihui 2,ZUO Qun 1,LIU Jin 2,LIU Shufang 1,DONG Yuping 1,LU Xiaofang 1   

  1. 1. College of Public Health of Hebei University，Baoding 071000，China;
    2. Department of Obstetrics and Gynecology,
  • Received:2014-03-14 Revised:2014-04-04 Published:2014-09-15 Online:2014-09-15
  • Contact: LIU Hui

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摘要：

【摘要】目的  研究DJ-1蛋白在卵巢癌患者血清中的表达水平及其意义。方法 选取卵巢上皮性肿瘤患者 52例为患者组，其中良性卵巢肿瘤9例，交界性卵巢肿瘤5例，卵巢癌38例；非卵巢肿瘤患者20例为对照组，采用双抗体夹心法测定2组患者血清中DJ-1蛋白的水平。结果 对照组血清中DJ-1蛋白水平明显低于各种卵巢肿瘤患者（P < 0.05）。卵巢癌患者血清DJ-1蛋白水平高于交界性卵巢肿瘤和良性卵巢肿瘤患者，交界性卵巢肿瘤高于良性卵巢肿瘤患者（P < 0.05）；低分化和中分化卵巢癌患者血清DJ-1水平均高于高分化卵巢癌患者（P < 0.05）；不同手术病理分期和不同组织学分类的卵巢癌患者血清DJ-1水平差别无统计学意义（P > 0.05）。结论  DJ-1参与了卵巢癌的发生和发展，可作为卵巢癌诊断及预后预测的血清学指标。

关键词: 卵巢肿瘤, 癌, DJ-1蛋白

Abstract:

[Abstract] Objective  To investigate serum DJ- 1 expression and its significance in ovarian cancer. Methods  The expression levels of DJ-1 protein were detected by double antibody sandwich method in 52 cases of ovarian tumors (9 cases of benign ovarian tumors, 5 cases of borderline ovarian tumors and 38 cases of ovarian cancer,ovarian tumor group and 20 non-ovarian tumors (control group). Results  The expression of DJ-1 protein was lower in the control group than that in ovarian tumor group (P < 0.05). The expression of serum DJ-1 protein was higher in ovarian cancer than that in borderline ovarian tumors and in benign ovarian tumors. The expression of serum DJ-1 protein was higher in borderline ovarian tumors than that in benign ovarian tumors (P < 0.05).The expression of serum DJ-1 protein was higher in poorly differentiated and moderately differentiated ovarian cancer than that in high-grade differentiated ovarian cancer (P < 0.05). No significant dif? ference was found in the expression serum of DJ-1 protein between different pathological and different histological types of ovarian cancer (P > 0.05). Conclusion  DJ-1 might be used as a serum marker in the diagnosis of ovarian cancer. It might be involved in the pathogenesis of ovarian cancer，and could predit the development and prognosis of ovarian cancer.

Key words: ovarian neoplasms, carcinoma, DJ-1