天津医药

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基于生物力学的干细胞调控及相关物理性质的测定

陈以胜1,李晓红1,张赛2   

  1. 1. 武警后勤学院附属医院脑研所
    2. 天津武警医学院附属医院
  • 收稿日期:2014-04-16 修回日期:2014-05-26 出版日期:2014-10-15 发布日期:2014-10-15
  • 通讯作者: 张赛

Stem Cells Regulation Based On the Biomechanics and the Measurement of Associated Physical Properties

  • Received:2014-04-16 Revised:2014-05-26 Published:2014-10-15 Online:2014-10-15

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摘要：

【摘要】干细胞移植对许多疾病有治疗作用，但移植部位微环境的改变会影响干细胞的生长、迁移及分化等一系列进程。目前对化学微环境如缺氧、神经生长因子、某些离子等的研究较为深入，并形成了相应的针对临床的治疗措施，但对移植相关的物理微环境知之甚少，对损伤相关的机械力、基质弹性和硬度等力学因素的调控及检测有待进一步研究。本文就力学微环境对干细胞的影响以及相关物理指标的测定方法进行综述

关键词: 干细胞, 细胞外基质, 力学信号转导, 原子力显微镜

Abstract: Abstract：Stem cells transplantation had been proved to be effective in many clinical diseases, however, the microenvironment wherein can influence the growth, migration and differentiation of stem cells. While the chemical microenvironment, such as hypoxia, neural growing factors and different kinds of ions, had been intensively studied, little about the physical microenvironment was presented. Mechanical forces, elasticity and rigidity of the matrix still need further investigation. This article is to summarize how the microenvironment controls the fate of stem cells, and the measurement of the mechanical properties.

Key words: stem cells, extracellular matrix (ECM), mechanotransduction, Atomic Force Microscope (AFM)