天津医药

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脑梗死后血管性痴呆发病危险因素研究

卢红艳,程焱   

  1. 天津医科大学总医院
  • 收稿日期:2012-01-17 修回日期:2012-03-22 出版日期:2012-06-15 发布日期:2012-06-15
  • 通讯作者: 卢红艳

Risk factors of vascular dementia after Cerebral Infarction

  • Received:2012-01-17 Revised:2012-03-22 Published:2012-06-15 Online:2012-06-15

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摘要： 摘要 目的：探讨脑梗死后血管性痴呆（VD）的发病危险因素。方法：随机选择392例急性脑梗死患者，收集临床及实验室资料，采用多因素Logistic回归分析，分析脑梗死后VD发病危险因素。结果：84名患者诊断为VD（21.4%）。单因素分析中，VD与病灶的数目、部位，脑萎缩及WMLs相关，多因素分析中发现左侧或双侧大脑半球病变、病灶的数目和脑萎缩为VD发病的独立危险因素，OR值分别为8.958、1.375和2.297。2组间一般情况，血脂水平无差异（P ﹥0.05）。结论 脑梗死后VD很常见，小血管病变是VD的主要类型，应早期进行针对性的预防和治疗，以减少和延缓VD的发生。

关键词: 血管性痴呆, 危险因素, 脑梗死

Abstract: Abstract Objective: To examine correlation factors for vascular dementia （VD）after cerebral infarction. Methods: A total of 392 patients were enrolled, and related clinical data and laboratory examinations were collected. Risk factors for VD were determined by using multiple logistic regression analysis. Results: Eighty-four participants (21.4%) were diagnosed as VD. Univariate analysis found that VD was associated with number of lesions, location of lesions, leukoaraiosis and cerebral atrophy. Multivariate logistic regression suggested that left hemisphere or bilateral lesions (OR=8.958) 、number of lesions(OR=1.375) and cerebral atrophy(OR=2.297) were independent risk factors of VD. VD was unrelated to age, education, or vascular factors (hypertension, diabetes, coronary heart disease, or hyperlipidemia ). Conclusions: Vascular dementia is frequent after ischemic stroke. Cerebral small vessel disease (SVD) is a major cause of VD. Better knowledge of the risk factors for VD should be emphasized to reduce the attacks of vascular dementia.

Key words: vascular dementia, risk factors, cerebral infarction