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原发性高血压患者血清Apelin的变化及其与糖脂代谢的关系

梁晓玲1,冀秋娣2   

  1. 1. 天津医科大学总医院代谢科
    2. 总医院内八病区
  • 收稿日期:2011-07-06 修回日期:2012-02-01 出版日期:2012-06-15 发布日期:2012-06-15
  • 通讯作者: 冀秋娣

The characteristics of serum Apelin and its relationship to glucose and lipid metabolism of essential hypertension

  • Received:2011-07-06 Revised:2012-02-01 Published:2012-06-15 Online:2012-06-15

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摘要： 摘要　目的：探讨原发性高血压及原发性高血压合并2型糖尿病患者血清Apelin的变化及其与血脂的关系。方法：选取原发性高血压患者34例，原发性高血压合并2型糖尿病者35例及正常对照者19例，采用酶联免疫吸附法测定血清Apelin水平，同时测定总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白、空腹血糖。结果：原发性高血压组及原发性高血压合并2型糖尿病组血清Apelin水平均明显高于正常对照组 (P<0.05)，原发性高血压组血清Apelin水平明显低于原发性高血压合并2型糖尿病组 (P<0.05)。血清Apelin与收缩压、舒张压、平均动脉压、空腹血糖、体质量指数、甘油三酯呈正相关(r=0.332、0.344、0.365、0.379、0.7360、0.338，均P<0.05)，与高密度脂蛋白成负相关（r=-0.251，P<0.05）。结论：原发性高血压患者血清Apelin水平可升高，血清Apelin水平与肥胖，糖脂代谢有关。

关键词: 　Apelin, 高血压, 糖尿病, 2型

Abstract: 【Abstract】　Objective　To investigate the characteristics of Apelin in serum and its relationship to plasma lipid profil of essential hypertension(EH) and EH complicated with diabetes mellitus type 2(T2DM). Methods　34 patients with EH, 35 patients with EH and T2DM(EH+T2DM) and 19 healthy subjects of control group(NC) were selected, to measure the serum level of Apelin in each group by enzyme linked immunosorbent assay(ELISA)and also measure the totel cholesterol(TC)，triglyceride(TG)，high-density lipoprotein(HDL)， low-density lipoprotein(LDL)and fasting plasma glucose(FPG). Results The serum levels of Apelin in the group of EH and EH+T2DM were significantly higher than that in the group of NC(P<0.05)，the serum level of Apelin in the group of EH was significantly lower than that in the group of EH+T2DM (P<0.05).There were positive correlation between the serum apelin and systolic pressure(SP)，diastolic pressure(DP)，mean arterial pressure(MAP)，FPG，body mass index(BMI) and TG，and negative correlation between it and the HDL. Conclusion The serum level of Apelin in the group of EH may be high，and the serum level of Apelin is related with obesity，glucose and lipid metabolism.

Key words: Apelin, hypertension, diabetes mellitus, type 2