天津医药

天津医药 ›› 2016, Vol. 44 ›› Issue (5): 649-652.doi: 10.11958/20150149

• 综述 • 上一篇    下一篇

一氧化氮合酶、环氧合酶与女性压力性尿失禁的关系

柯健， 方克伟△   

  1. 昆明医科大学第二附属医院泌尿外科 （邮编 650101）
  • 收稿日期:2015-09-07 修回日期:2015-12-16 出版日期:2016-05-15 发布日期:2016-05-18
  • 通讯作者: △通讯作者 E-mail:fkw_waley@126 E-mail:kejian_1989@163.com
  • 作者简介:柯健 （1989）， 硕士在读， 主要从事压力性尿失禁的基础与临床研究
  • 基金资助:
    云南省科技计划项目 （2012FB048）； 昆明医科大学研究生创新基金 （2015S95）

Relationship between nitric oxide synthase and cyclooxygenase in female stress urinary incontinence

KE Jian, FANG Kewei△   

  1. Department of Urology, the Second Affiliated Hospital of Kunming Medical University, Kunming 650101, China
  • Received:2015-09-07 Revised:2015-12-16 Published:2016-05-15 Online:2016-05-18
  • Contact: △Corresponding Author E-mail： fkw_waley@126.com E-mail:kejian_1989@163.com

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摘要： 摘要： 女性压力性尿失禁（FSUI）严重影响中老年女性身心健康， 已成为女性泌尿外科常见的疾病， 其分子学机制尚不清楚。一氧化氮合酶（NOS）和环氧合酶（COX）及其各自的催化产物一氧化氮（NO）和前列腺素（PG）与 FSUI 有密切联系。本文就 NOS 和 COX 在女性下尿路的分布及其在 FSUI 中的研究进展进行综述。

关键词: 尿失禁, 压力性, 一氧化氮合酶, 一氧化氮, 前列腺素, 环氧合酶, 综述

Abstract: Abstract:Female stress urinary incontinence (FSUI) is a common disease of women in department of urology, which severely affects elderly physical and mental health of women. The molecular mechanism of FSUI is still unclear. Nitric oxide synthase (NOS), cyclooxygenase (COX) and their respective products nitric oxide (NO) and prostaglandin (PG) are closely related with FSUI. In this paper, the distribution of NOS and COX in female lower urinary tract and the research development of NOS, COX and their products with FSUI are summarized.

Key words: urinary incontinence, stress, nitric oxide synthase, nitric oxide, prostaglandins, cyclooxygenase, review