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唐山地区成人社区获得性肺炎致病菌流行病学调查

刘向欣   

  1. 河北联合大学附属开滦总医院感染管理科
  • 收稿日期:2013-04-08 修回日期:2013-06-27 出版日期:2013-12-15 发布日期:2013-12-15
  • 通讯作者: 刘向欣

Pathogen Epidemiology of Community-Acquired Pneumonia in Adults of Tangshan Area

LIU Xiang xin   

  1. The Affiliated Kailuan Hospital of Hebei United University
  • Received:2013-04-08 Revised:2013-06-27 Published:2013-12-15 Online:2013-12-15
  • Contact: LIU Xiang xin

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摘要：

【摘要】  目的  了解唐山地区成人社区获得性肺炎（CAP）致病菌分布情况。  方法  采用多中心调查的方法，收集2011年10月—2012年9月期间，唐山市行政区域内6所医院呼吸内科530例确诊为CAP的成人住院患者的痰标本，并进行致病菌检测。  结果   530例CAP患者217株菌标本中，172例（32.45%）检测出致病菌195株，常见的致病菌为肺炎克雷伯菌64株（12.08%）、肺炎链球菌24株（4.53%）、鲍曼不动杆菌19株（3.58%）。肺炎克雷伯菌和铜绿假单胞菌在有基础疾病的患者中检出率高于无基础疾病患者（P＜0.05）；没有应用过抗生素CAP患者的肺炎克雷伯菌和肺炎链球菌分离率高于应用过抗生素者（P＜0.05）；肺炎克雷伯菌、鲍曼不动杆菌、铜绿假单胞菌在≥60岁年龄组的分离率高于＜60岁者（P＜0.05）；肺炎克雷伯菌的检出率随PORT级别的增加而相应增高（P＜0.05）；不同地区、季节致病菌的检出率差异无统计学意义（P＞0.05）。  结论  唐山地区成人CAP患者的致病菌以革兰阴性菌为主，肺炎克雷伯菌为首要致病菌；年龄≥60岁、入院前未应用过抗生素、合并基础疾病、PORTⅢ级以上病情较重患者的抗感染治疗应以抗革兰阴性菌治疗为主。

关键词: 肺炎, 机会致病菌感染, 流行病学研究, 成年人, 社区获得性肺炎

Abstract:

[Abstract]   Objective   To investigate the distribution of pathogens in adult patients with community-acquired pneumonia (CAP) in Tangshan area.   Methods   The clinical data of530hospitalized patients with CAP were retrospectively collected in department of respiratory medicine from6hospitals in Tangshan area from October2011to September2012. The sputum samples were isolated and cultured.  Results   A total of 195 strains were isolated from530patients with CAP. The most common types of pathogens includedKlebsiella pneumoniae(64strains,12.08%),Streptococcus pneumoniae(24strains,4.53%) andBauman Acinetobacter(19strain,3.58%). The detective rates ofKlebsiella pneumoniaeandPseudomonas aeruginosawere significantly higher in patients with basic diseases than those of patients without basic diseases (P<0.05). The detective rates ofKlebsiella pneumoniaeandStreptococcus pneumoniaewere significantly higher in patients not taking antibiotics than those of patients taking antibiotics (P<0.05). The detective rates of Klebsiella pneumoniae, Bauman AcinetobacterandPseudomonas aeruginosa were significantly higher in the age group≥60years than those in the age group <60years (P<0.05). The detective rates of Klebsiella pneumoniaewere significantly increased with increased levels of PORT (P<0.05). There were no significant differences in the detective rates of pathogens between different regions and different seasons (P>0.05).  Conclusion   The gram-negative bacterial pathogens were the majority isolated from patients with CAP in Tangshan area. And Klebsiella pneumoniaewas the primary bacteria. Patients with serious illness, above60years old, without antibiotic treatment before hospitalization, with basic diseases and above PORT Ⅲ levels should be given treatment of anti-gram-negative bacteria.

Key words: pneumonia, opportunistic infections, epidemiologic studies, adult, community acquired pneumonia