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系统性红斑狼疮患者血清骨桥蛋白检测及意义

周蕾1,杜晓敏2,3,张宗芳2,3,王坤坤2,3   

  1. 1. 天津医科大学总医院 感染免疫科
    2.
    3. 天津医科大学总医院
  • 收稿日期:2010-10-09 修回日期:2011-07-05 出版日期:2011-11-15 发布日期:2011-11-15
  • 通讯作者: 周蕾

The Clinical Significance of Serum Osteopontin in Systemic Lupus Erythematosus

  • Received:2010-10-09 Revised:2011-07-05 Published:2011-11-15 Online:2011-11-15
  • Contact: Lei ZHOU

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摘要： 摘要 目的：探讨血清骨桥蛋白（OPN）水平与系统性红斑狼疮（SLE）脏器受累及疾病活动的关系。方法：63例SLE患者依据疾病活动指数（SLEDAI）分为缓解组（0~8分）31例和活动组（≥9分）32例；依据肾功能、尿液分析及肾脏病理检查结果分为肾损害组（32例）和无肾损害组（31例）；依据肺间质有无纤维化将患者分为合并肺间质病变（ILD）组22例和未合并ILD组 41例；依据心电图、心脏彩色多普勒超声检查及心肌酶检查，分为心脏损害组25例和无心脏损害组38例；依据血常规检查结果分为合并血液系统损害组45例和无血液系统损害18例。采用酶联免疫吸附（ELISA）法检测上述SLE患者血清OPN水平，并与20例健康体检者（对照组）进行比较。结果：SLE患者血清OPN水平显著高于对照组（均P <0.05或P ＜ 0.01）。SLE合并肾损害、肺间质病变、心脏损害、血液系统损害组的血清OPN水平明显高于无相应脏器受累患者（均P ＜ 0.01），SLE患者的血清OPN水平与SLEDAI评分呈显著正相关（r=0.982，P＜0.01）。结论： OPN在SLE发病机制中具有一定意义，并与疾病活动、脏器损害相关，血清OPN水平可以作为判断SLE疾病活动的实验室指标。

关键词: 红斑狼疮, 系统性, 骨桥蛋白

Abstract: Abstract Objective：To investigate the association between serum level of osteopontin (OPN), disease activity and organ damage of systemic lupus erythematosus (SLE). Methods：Six-three SLE patients and 20 healthy, age- and sex-matched controls were enrolled in this study. According to the systemic lupus erythematosus disease activity index (SLEDAI)，patients were divided into renal damage group (0-8 score，n=32) and without renal damage group (≥9 score，n=31). According to the interstitial pulmonary fibrosis index, patients were divided into interstitial lung disease (ILD) group (n=22) and without ILD group (n=41). Patients were also divided into heart damage group (n=25) and without heart damage group (n=38) according to the electrocardiogram，echocardiogram and cardiac enzyme results. Based on hematological results, patients were divided into with cytopenia group (n=45) and without cytopenia group (n=18). The serum level of OPN was detected by enzyme-linked immunosorbent assay (ELISA) in patients of groups. Results：The serum level of OPN was significantly higher in SLE group than that of healthy controls (P<0.05 or P＜0.01). The serum level of OPN was significantly higher in patients with renal damage, lung interstitial disease, heart damage and cytopenia than that of patients without organ involvement in SLE (P＜0.01). The serum level of OPN was significantly positively correlated with SLEDAI in SLE patients (r=0.982，P＜0.01). Conclusion：OPN plays a role in the pathogenesis of SLE and is related to the disease activity and organ damage. OPN may serve as an active disease laboratory marker of SLE.

Key words: lupus erythematosus, systemic, osteopontin