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2型糖尿病患者肥胖不同指标与尿微量白蛋白关系的探讨

张琳1,张雅静2,赵伟2,张宏3,李文静2   

  1. 1. 天津医科大学代谢病医院9楼
    2. 天津医科大学代谢病医院
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  • 收稿日期:2011-03-21 修回日期:2011-08-26 出版日期:2012-01-15 发布日期:2012-01-15
  • 通讯作者: 张琳

Relationship between Microalbuminuria and body mass index 、waist to hip ratio and Waist to height ratio in Patients with Type 2 Diabetes

  • Received:2011-03-21 Revised:2011-08-26 Published:2012-01-15 Online:2012-01-15

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摘要： 目的：探讨2型糖尿病（T2DM）患者尿微量白蛋白（UMA）的发生与肥胖的不同指标之间的关系。方法：292例T2DM患者根据体重指数（BMI）分为正常体重组（88例）和超重组（121例）和肥胖组（83例），分析各组24h尿微量白蛋白变化及其影响因素。结果：三组间比较,随着BMI的增加,腰臀比(WHR)、腰围身高比（WHtR）、24小时尿微量白蛋白（MAU）、舒张压(DBP)呈上升趋势，差异具有统计学意义（P<0.01或P<0.05）；相关性分析结果表明MAU与病程、WHtR、WHR、BMI、SBP、DBP呈显著正相关（P<0.01或P<0.05）；多元逐步回归分析结果表明WHtR、SBP与UMA呈独立正相关（P<0.05或P<0.01）。结论： WHtR较大的T2DM患者微量白蛋白尿发生的可能性较大，腹型肥胖是微量白蛋白尿的危险因素。

关键词: 微量白蛋白尿, 糖尿病, 2型, 体重指数, 腰臀比, 腰围身高比

Abstract: Abstract Objective:To investigate the relationship between microalbuminuria and the indeces of fat. Methods:.Based on the results of the body mass index（BMI）,the 292 type 2 diabetes mellitus(T2DM) patients were divided into normal weight group（88 cases）,overweight group (121 cases)and obesity group(83cases).The differences of 24h urinary microalbumin(UMA) were compared among the three groups,and therefore,the factors that influence UMA were drawed. Results:There were significant differences in the values of BMI、waist-to-hip ratio(WHR)、waist –to-height ratio(WHtR)、UMA、systolic pressure(DBP) among three groups（P<0.01 or P<0.05）；Correlation analysis showed a positive correlation between UMA and the duration of the disease, WHtR,WHR,BMI,SBP,DBP(P<0.01 or P<0.05).Multiple stepwise regression analysis showed WHtR,SBP were independent risk factors of UMA(P<0.05 or P<0.01). Conclusion:The possibility of having UMA was significantly increased in T2DM patients with higher WHtR;The abdorminal obesity is an risk factor of UMA in T2DM patients.

Key words: microalbuminuria, diabetes mellitus, type 2, body mass index, waist to hip ratio, waist to height ratio