天津医药

• 论著 • 上一篇    下一篇

非酒精性脂肪肝患者检测血清胸腺素β4水平的意义*

董秋艳1,韩涛2,刘莹2,王博3,朱争艳3,李岩4,肖时湘4   

  1. 1. 北京武警总队第二医院
    2. 天津医科大学第三中心医院
    3. 天津医科大学第三中心临床学院
    4. 天津市第三中心医院
  • 收稿日期:2011-11-04 修回日期:2012-03-23 出版日期:2013-02-15 发布日期:2013-02-15
  • 通讯作者: 董秋艳

The Significance of Serum Thymosin β4 Levels in Patients with Non-alcoholic Fatty Liver Disease

  • Received:2011-11-04 Revised:2012-03-23 Published:2013-02-15 Online:2013-02-15
  • Contact: DONG Qiu yan

PDF (PC)

2320

摘要：

 目的 检测非酒精性脂肪肝（NAFLD）患者血清胸腺素β4（Tβ4）的水平，并探讨其与患者生化指标的相关性。方法 检测40 例NAFLD 患者血清Tβ4 及生化指标，并与健康对照组40 例比较。同时检测其中26 例 NAFLD患者接受水飞蓟宾或多烯磷脂酰胆碱治疗前后血清生化指标和Tβ4的水平。分别做受试者血清ALT、Tβ4水平特征曲线（ROC），比较两者对NAFLD的诊断，并对诊断界点（cut-off 值）进行确定。结果 NAFLD患者血清Tβ4水平明显低于对照组（P ＜0.01）。NAFLD组患者血清Tβ4水平与其血清ALT含量呈负相关（r=-0.330，P ＜0.05）。26例 NAFLD患者治疗后血清Tβ4的水平高于治疗前的水平（P ＜0.01）。NAFLD组患者与对照组、NAFLD组患者治疗前后血清中TG、ALT、ASTm、GGT、TBIL、ALP、ALB、FPG的比较，差异均有统计学意义(P ＜0.05或P ＜0.01）。血清Tβ4与 ALT比较的ROC曲线显示，血清Tβ4的曲线下面积（AUC）为0.906，cut-off值为4.830 5 mg/L，其灵敏度为85%、特异度 80%均高于血清ALT。结论 NAFLD患者血清Tβ4的水平明显降低，治疗好转后升高。血清Tβ4的水平比ALT能更灵敏地反映NAFLD患者的肝脏功能。

关键词: 非酒精性脂肪肝, 胸腺素β4, 再生, 氧化应激, 转录因子核因子

Abstract:

[Abstract] Objective  To investigate serum thymosin β4 (Tβ4) levels in patients with non-alcoholic fatty liver disease (NAFLD)，and to explore the correlation between Tβ4 and serum biochemical parameters. Methods The serum Tβ4 level and biochemical parameters were detected in 40 putients with NAFLD. In addition, the levels of serum Tβ4 and biochemical parameters were detected before and after treatment with silibinin or polyene phosphatidylcholine in 26 NAFLD patients. The receiver operator characteristic (ROC) analyses for ALT and Tβ4 level were performed and cut-off value was determined. Results  Compared with the healthy control group, serum Tβ4 levels were significantly lower in patients with NAFLD (P＜ 0.01). There was a negative correlation between serum Tβ4 and ALT in patients with NAFLD（r=-0.330，P＜0.05). The serum level of Tβ4 was significantly increased after treatment in 26 NAFLD patients (P＜0.01). There were significant differences in levels of TG，ALT，ASTm，GGT，TBIL，ALP，ALB and FPG between NAFLD group and healthy control group (P＜0.05 or P＜ 0.01). After treatment, the levels of TG，ALT，ASTm，GGT，TBIL，ALP，ALB and FPG improved in patients with NAFLD (P＜ 0.05 or P＜0.01). AUC of serum Tβ4 was 0.906 with 4.830 5 mg /L cut off value. Its sensitivity was 85% and specificity was 80%, which were higher than those of ALT. Conclusion  The serum levels of Tβ4 were significantly lower in NAFLD patients than those of healthy control. And the level of serum Tβ4 was significantly increased after treatment in NAFLD patients. The serum level of Tβ4 was a more sensitive index than ALT for patients with NAFLD.

Key words: Non-alcoholic fatty liver disease, Thymosin β4, Regeneration, Oxidative Stress, NF–κB