天津医药

• 药物临床观察 • 上一篇    下一篇

负压吸引术前应用卡孕栓或米索所致所致不良反应比较

谢娟,王颖,于晓兰,吴北生,马健   

  1. 北京大学第一医院妇产科
  • 收稿日期:2012-07-23 修回日期:2012-11-27 出版日期:2013-04-15 发布日期:2013-04-15
  • 通讯作者: 谢娟

Clinical analysis and nursing countermeasures of two preoperative drugs’ adverse effects

  • Received:2012-07-23 Revised:2012-11-27 Published:2013-04-15 Online:2013-04-15
  • Contact: XIE juan

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摘要：

【摘要】目的 分析比较卡孕栓及米索前列醇（米索）所致不良反应。方法 100例要求终止妊娠的健康早孕女性，按随机数字表法分为卡孕栓组和米索前列醇组，每组50例。观察用药后不良反应。负压吸引术前0.5 h分别肛塞卡孕栓0.5 mg或含服米索200 μg。用药后0.5~24 h，观察并记录2组患者的最高体温及出现时间和不良反应的发生情况及持续时间。结果 卡孕栓组恶心呕吐者多于米索组，腹痛者少于米索组，不良反应持续时间低于米索组，差异有统计学意义（P＜0.05）。结论胃肠道不适的早孕女性负压吸引术前不宜肛塞卡孕栓。

关键词: 卡孕栓, 米索前列醇, 药物不良反应, 护理

Abstract: Objective: To analyze the characteristics and related factors of adverse effects caused by PG05 and misoprostol, providing the nursing guidance of drugs’ adverse effects. Methods: To choose 100 healthy early-pregnant patients with requirement of pregnancy termination hospitalized in Peking University 1st Hospital from Oct.2011 to Dec.2011. They were randomly divided into two groups, PG05 group (50 cases) and misoprostol group (50 cases). Adverse effects were observed after drug application. Insert into anus 0.5mg pG05 or Oral 200ug misoprostol 30 minutes before negative pressure suction surgery. Record blood pressure, pulse, the highest temperature and the time it occurs, nausea and vomiting frequency, diarrhea frequency and breath 30 minutes after medication. Record the occurrence of headache, dizziness, weakness, breast tenderness, abdominal pain, chills and skin rash. Provide nursing intervention aiming at the adverse response of patients after medication. Results: Thirty minutes after medication, we have observed that 16 patients of PG05 group (32 percent) appear symptoms of nausea and vomiting, significantly more than misoprostol group, which occurs 6 cases (12 percent).The difference has statistical significance (P<0.05). No one has abdominal pain in PG05 group. 7 patients of misoprostol group (14 percent) appear symptom of abdominal pain. The difference has statistical significance (P<0.05). The difference of diarrhea, weakness, headache and dizziness, palm itching and other adverse responses between two groups don’t have statistical significance (P>0.05). Patients can tolerate adverse responses above. Conclusions: Women who have gastrointestinal discomfort in early pregnancy aren’t fit for inserting into anus progesterone before negative pressure suction surgery. Nurses master characteristics of two drugs’adverse responses in detail, which has significance for directing nursing process. Besides, it lets women of childbearing age enjoy high-quality services.

Key words: PG05, misoprostol, drug adverse effect, nursing care