天津医药

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高压氧对重型颅脑创伤患者治疗作用的临床研究

王延民1,孟艳丽1,张赛2   

  1. 1. 天津医科大学
    2. 天津武警医学院附属医院
  • 收稿日期:2009-12-10 修回日期:2010-01-01 出版日期:2010-05-15 发布日期:2010-05-15
  • 通讯作者: 王延民

A Clinical Study of The Therapeutic Effect of Hyperbaric Oxygen in Patients with Severe Traumatic Brain Injury

  • Received:2009-12-10 Revised:2010-01-01 Published:2010-05-15 Online:2010-05-15
  • Contact: WANG Yan-min

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摘要： 目的：研究高压氧治疗在改善重型颅脑创伤患者预后方面的作用。方法：随机选取60例重型颅脑创伤患者，入院时GCS评分在3-8分之间，入院后均行开颅手术，术后将患者随机分成两组，其中30例患者（Ⅰ组）给予常规药物治疗，另外30例患者（Ⅱ组）在常规药物治疗基础上，第10天开始给予高压氧治疗,疗程为30天。结果：高压氧治疗满30天后，观察到Ⅱ组患者预后恢复情况（GCS评分以及动态脑电图监测恢复情况）明显优于Ⅰ组，用统计学方法处理观察指标，两组患者的观察指标差别具有统计学意义(P ＜0.05)。结论：高压氧治疗能显著提高重型颅脑创伤患者预后恢复的程度和速度，联合高压氧治疗组中患者预后好于单纯药物治疗组。

关键词: 高压氧治疗, 重型颅脑创伤, 预后, 动态脑电图

Abstract: Objective：To investigate the role of hyperbaric oxygen therapy in improving the outcome of patients with severe traumatic brain injury. Methods：Selected 60 cases of traumatic brain injury patients， whose GCS score were between 3-8 when registered，all of them were practiced surgical treatment， and then were randomly divided into two groups. Patients of groupⅠ(30 cases)suffered simple drug treatment， the rest of the patients in group Ⅱ were carried out not only drug treatment， but also hyperbaric oxygen therapy after the tenth day. Results：By comparing GCS score and ambulatory EEG monitoring， patients in group Ⅱ had faster restoration of outcome than the ones in groupⅠ after 30 days’ therapy. We observed that the targets of the two groups prompted visible difference. Conclusion：Hyperbaric oxygen therapy can improve the degree and rate of recovery of outcome in patients with severe traumatic brain injury. The patients in group Ⅱ had better outcome than group Ⅰ.

Key words: hyperbaric oxygen therapy, severe traumatic brain injury, outcome, ambulatory EEG