• 短篇论著 •    

高压氧对重型颅脑创伤患者治疗作用的临床研究

王延民1,孟艳丽1,张赛2   

  1. 1. 天津医科大学
    2. 天津武警医学院附属医院
  • 收稿日期:2009-12-10 修回日期:2010-01-01 出版日期:2010-05-15 发布日期:2010-05-15
  • 通讯作者: 王延民

A Clinical Study of The Therapeutic Effect of Hyperbaric Oxygen in Patients with Severe Traumatic Brain Injury

  • Received:2009-12-10 Revised:2010-01-01 Published:2010-05-15 Online:2010-05-15
  • Contact: WANG Yan-min

摘要: 目的:研究高压氧治疗在改善重型颅脑创伤患者预后方面的作用。方法:随机选取60例重型颅脑创伤患者,入院时GCS评分在3-8分之间,入院后均行开颅手术,术后将患者随机分成两组,其中30例患者(Ⅰ组)给予常规药物治疗,另外30例患者(Ⅱ组)在常规药物治疗基础上,第10天开始给予高压氧治疗,疗程为30天。结果:高压氧治疗满30天后,观察到Ⅱ组患者预后恢复情况(GCS评分以及动态脑电图监测恢复情况)明显优于Ⅰ组,用统计学方法处理观察指标,两组患者的观察指标差别具有统计学意义(P <0.05)。结论:高压氧治疗能显著提高重型颅脑创伤患者预后恢复的程度和速度,联合高压氧治疗组中患者预后好于单纯药物治疗组。

关键词: 高压氧治疗, 重型颅脑创伤, 预后, 动态脑电图

Abstract: Objective:To investigate the role of hyperbaric oxygen therapy in improving the outcome of patients with severe traumatic brain injury. Methods:Selected 60 cases of traumatic brain injury patients, whose GCS score were between 3-8 when registered,all of them were practiced surgical treatment, and then were randomly divided into two groups. Patients of groupⅠ(30 cases)suffered simple drug treatment, the rest of the patients in group Ⅱ were carried out not only drug treatment, but also hyperbaric oxygen therapy after the tenth day. Results:By comparing GCS score and ambulatory EEG monitoring, patients in group Ⅱ had faster restoration of outcome than the ones in groupⅠ after 30 days’ therapy. We observed that the targets of the two groups prompted visible difference. Conclusion:Hyperbaric oxygen therapy can improve the degree and rate of recovery of outcome in patients with severe traumatic brain injury. The patients in group Ⅱ had better outcome than group Ⅰ.

Key words: hyperbaric oxygen therapy, severe traumatic brain injury, outcome, ambulatory EEG