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结肠息肉、结肠癌患者HP感染与血浆胃泌素、COX-2表达的相关性

郑荣娟   

  1. 河北医科大学唐山临床学院（唐山工人医院）
  • 收稿日期:2011-11-26 修回日期:2012-02-27 出版日期:2012-07-15 发布日期:2012-07-15
  • 通讯作者: 郑荣娟

Study on the relationship between HP infection and the levels of plasma G-17, COX-2 of colon polyps, colon cancers

Rongjuan Zheng   

  • Received:2011-11-26 Revised:2012-02-27 Published:2012-07-15 Online:2012-07-15
  • Contact: Rongjuan Zheng

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摘要： 目的 探讨结肠息肉、结肠癌患者HP感染与血浆胃泌素(G-17)、COX-2表达的相关性。方法 选择结肠息肉、结肠癌、结肠镜检查阴性患者各60例，通过碳C13呼气试验检测HP感染、酶联免疫吸附法检测血浆G-17水平及免疫组化法检测COX-2的表达。结果 结肠息肉组、结肠癌组HP感染率明显高于对照组(P<0.05)。在正常对照、结肠息肉、结肠癌组中，HP阳性者血浆G-17水平明显高于HP阴性组(P<0.05)。在结肠息肉、结肠癌组中，HP阳性者COX-2的表达高于HP阴性组(P<0.05)。HP感染与COX-2的表达呈正相关(r＝0.538，P<0.05)。结论 HP感染可能通过影响血浆胃泌素-17及COX-2的水平在结肠息肉与结肠癌的发病过程中起一定作用。

关键词: 结肠息肉, 结肠癌, 幽门螺杆菌, 血浆胃泌素-17, COX-2

Abstract: Objective To study the relationship HP infection and plasma G-17, cyclooxygenase-2 (COX-2) expression of colon polyps, colon cancer. Methods To select colon polyps(n=60), colon cancer(n=60) and patients with negative colonoscopy examination (n=60). Through C13 breath test to detect HP infection，enzyme-linked immunosorbent assay to plasma G-17 and immunohistochemistry to COX-2 expression.Results H.P infection in patients with colon polyps，colon cancer was higher than that in normal group (P<0.05). In normal control group, colon polyps group and colon carcinoma group, plasma G-17 levels was higher in HP+ group than HP- group (all P<0.05). In colon polyps and cancer group, COX-2 expression in H.P+ group was higher than that in H.P- group (all P<0.05). In H.P- group, COX-2 expression in colon cancer higer than of colon polyps (P<0.05). In H.P+ group, COX-2 expression in colon cancer higer than that in colon polyps (P<0.05). HP infection and COX-2 expression was positively correlated (r = 0.538, P<0.01). Conclusions HP infection may be related to the development of colon polyps, colon cancer through affecting the expression of plasma G -17 and COX-2 .

Key words: Colon polyps, Colon cancer, H. P, Gastrin-17, COX-2