季节与气温变化对急性脑梗死患者血糖水平的影响

doi:10.11958/20212829

天津医药 ›› 2022, Vol. 50 ›› Issue (8): 836-839.doi: 10.11958/20212829

季节与气温变化对急性脑梗死患者血糖水平的影响

魏妙妙¹(), 夏晓爽¹, 王林², 李新¹^,³^,^Δ()

1天津医科大学第二医院神经内科（邮编300211）
2保健医疗部/老年病科, 天津医科大学第二医院（邮编300211）
3天津市健康气象交叉创新中心

收稿日期:2021-12-23 修回日期:2022-03-24 出版日期:2022-08-15 发布日期:2022-08-12
通讯作者: 李新 E-mail:weimiaomiao18@163.com;jessielx@126.com
作者简介:魏妙妙（1992）,女,住院医师,主要从事气象因素与脑血管病关系方面研究。E-mail： weimiaomiao18@163.com
基金资助:
天津市科学技术委员会重大专项(18ZXDBSY00210);中国脑卒中高危人群干预适宜技术研究及推广项目(GN-2020R0005)

Effects of seasonal and temperature changes on blood glucose levels in patients with acute cerebral infarction

WEI Miaomiao¹(), XIA Xiaoshuang¹, WANG Lin², LI Xin¹^,³^,^Δ()

1 Department of Neurology, the Second Hospital of Tianjin Medical University, Tianjin 300211, China
2 Department of Geriatrics, the Second Hospital of Tianjin Medical University, Tianjin 300211, China
3 Center for Interdisciplinary Innovation in Health and Meteorology

Received:2021-12-23 Revised:2022-03-24 Published:2022-08-15 Online:2022-08-12
Contact: LI Xin E-mail:weimiaomiao18@163.com;jessielx@126.com

魏妙妙, 夏晓爽, 王林, 李新. 季节与气温变化对急性脑梗死患者血糖水平的影响[J]. 天津医药, 2022, 50(8): 836-839.

WEI Miaomiao, XIA Xiaoshuang, WANG Lin, LI Xin. Effects of seasonal and temperature changes on blood glucose levels in patients with acute cerebral infarction[J]. Tianjin Medical Journal, 2022, 50(8): 836-839.

摘要/Abstract

摘要：

目的探讨季节与气温变化对急性脑梗死患者血糖水平的影响。方法回顾性分析急性脑梗死患者1 260例及同期气象资料,收集所有患者一般资料和常规血液学检查结果,分析急性脑梗死患者血糖水平的季节性变化及气温与血糖水平的相关性。结果急性脑梗死患者冬季血压、体质量指数、基线美国国立卫生研究院卒中量表评分、总胆固醇及合并糖尿病患者的空腹血糖水平均高于夏季（P<0.05）。当糖化血红蛋白≥7%时,其春季水平高于其他季节（P<0.05）。空腹血糖水平在1月达到高峰,7月达到低谷,糖化血红蛋白水平则在2月达到高峰,8月达到低谷。血糖水平呈现随气温降低而升高的趋势,且气温对糖化血红蛋白的影响存在滞后效应。将气温与血糖水平进行Spearman秩相关检验,发现空腹血糖与月均每日平均气温、月均每日最低气温、月均每日最高气温均呈显著负相关（r_s分别为-0.690、-0.637、-0.764,均P<0.05）;糖化血红蛋白与滞后2个月的月均每日平均气温、月均每日最低气温、月均每日最高气温呈显著负相关（r_s分别为-0.729、-0.750、-0.743,均P<0.05）。结论急性脑梗死合并糖尿病患者冬季血糖水平高于其他季节,且月均每日平均气温、月均每日最低气温、月均每日最高气温均与血糖水平呈负相关。

关键词: 脑梗死, 急性病, 糖尿病, 血糖, 血红蛋白A,糖基化, 季节, 气候, 温度

Abstract:

Objective To investigate the effects of seasonal and temperature changes on blood glucose levels in patients with acute cerebral infarction. Methods The meteorological data of 1 260 cases with acute cerebral infarction were retrospectively analyzed. The baseline clinical data and blood test results were collected. The correlation between blood glucose levels in patients with acute cerebral infarction and seasonal and temperature changes were analyzed. Results The blood pressure, body mass index, baseline National Institutes of Health Stroke Scale score, total cholesterol and fasting plasma glucose (FPG) of patients with acute cerebral infarction were significantly higher in winter than those in summer (P<0.05). When the glycated hemoglobin A1c (HbA1c) level was ≥7%, the above indicators in spring were higher than those in other seasons (P<0.05). FPG levels peaked in January and bottomed in July, while HbA1c levels peaked in February and bottomed in August. Glucose levels showed a tendency to increase with the decrease of temperature. There was a lag effect of temperature on HbA1c. Spearman correlation test was performed on temperature and glucose levels. It was found that FPG levels were negatively correlated with monthly mean daily temperature, monthly minimum daily temperature and monthly maximum daily temperature (r_s=-0.690, -0.637, -0.764, respectively, all P<0.05). HbA1c levels were negatively correlated with monthly mean daily temperature, monthly minimum daily temperature and monthly maximum daily temperature with a two-month lag (r_s=-0.729, -0.750, -0.743, respectively, all P<0.05). Conclusion The blood glucose level of patients with acute cerebral infarction complicated with diabetes is higher in winter than that in other seasons. The monthly mean daily temperature, monthly minimum temperature and monthly maximum temperature are negatively correlated with blood glucose level.

Key words: brain infarction, acute disease, diabetes mellitus, blood glucose, hemoglobin A, glycosylated, seasons, climate, temperature

中图分类号:

R743.33

图/表 4

表1 不同季节发病的急性脑梗死患者基线资料比较

Tab.1 Comparison of general data of patients with acute cerebral infarction between different seasons

表2 患者血液学指标结果比较

Tab.2 Comparison of blood metabolic index results between the four groups

图1 不同月份空腹血糖水平与气温变化趋势

Fig.1 The trends of fasting plasma glucose levels and temperature in different months

图2 不同月份糖化血红蛋白水平与滞后2个月气温变化趋势

Fig.2 Changes of glycated hemoglobin A1c levels in different months and temperature with a two-month lag

参考文献 15

[1]	KURTZ P, BASTOS L S, AGUILAR S, et al. Effect of seasonal and temperature variation on hospitalizations for stroke over a 10-year period in Brazil[J]. Int J Stroke, 2021, 16(4):406-410. doi: 10.1177/1747493020947333.
[2]	FERRARI F, MORETTI A, VILLA R F. Hyperglycemia in acute ischemic stroke: physiopathological and therapeutic complexity[J]. Neural Regen Res, 2022, 17(2):292-299. doi: 10.4103/1673-5374.317959.
[3]	TAKAI M, ISHIKAWA M, MAEDA H, et al. A study of seasonal variation in the effect of add-on sitagliptin on blood glucose control in insulin-treated patients with type 2 diabetes[J]. J Clin Med Res, 2020, 12(3):200-208. doi: 10.14740/jocmr4103.
[4]	中华医学会神经病学分会, 中华医学会神经病学分会脑血管病学组. 中国急性缺血性脑卒中诊治指南2018[J]. 中华神经科杂志, 2018, 51(9):666-682.
	Neurology of Chinese Medical Association,Cerebrovascular Disease Group of Neurology of Chinese Medical Association. Guidelines for the diagnosis and treatment of acute ischemic stroke in China 2018[J]. Chinese Journal of Neurology, 2018, 51(9):666-682. doi: 10.3760/cma.j.issn.1006-7876.2018.09.004.
[5]	中华医学会糖尿病学分会. 中国2型糖尿病防治指南(2020年版)[J]. 中华糖尿病杂志, 2021, 13(4):315-409.
	Diabetes Society of Chinese Medical Association. Guidelines for the prevention and treatment of type 2 diabetes mellitus in China (2020 edition)[J]. Chinese Journal of Diabetes, 2021, 13(4):315-409. doi: 10.3760/cma.j.cn115791-20210221-00095.
[6]	LIANG W W. Seasonal changes in preprandial glucose,A1C,and blood pressure in diabetic patients[J]. Diabetes Care, 2007, 30(10):2501-2502. doi: 10.2337/dc07-0597.
[7]	ZHANG Y, TONG M, WANG B, et al. Geographic,gender,and seasonal variation of diabetes:a nationwide study with 1.4 million participants[J]. J Clin Endocrinol Metab, 2021, 106(12):e4981-e4992. doi: 10.1210/clinem/dgab543.
[8]	SAILANI M R, METWALLY A A, ZHOU W, et al. Deep longitudinal multiomics profiling reveals two biological seasonal patterns in California[J]. Nat Commun, 2020, 11(1):4933. doi: 10.1038/s41467-020-18758-1.
[9]	PEREIRA M T, LIRA D, BACELAR C, et al. Seasonal variation of haemoglobin A1c in a Portuguese adult population[J]. Arch Endocrinol Metab, 2015, 59(3):231-235. doi: 10.1590/2359-3997000000043.
[10]	KIM Y J, PARK S, YI W, et al. Seasonal variation in hemoglobin A1c in Korean patients with type 2 diabetes mellitus[J]. J Korean Med Sci, 2014, 29(4):550-555. doi: 10.3346/jkms.2014.29.4.550.
[11]	TOYODA K, KOGA M, YAMAGAMI H, et al. Seasonal variations in neurological severity and outcomes of ischemic stroke- 5-year single-center observational study[J]. Circ J, 2018, 82(5):1443-1450. doi: 10.1253/circj.CJ-17-1310.
[12]	HIGGINS T, SAW S, SIKARIS K, et al. Seasonal variation in hemoglobin A1c:is it the same in both hemispheres?[J]. J Diabetes Sci Technol, 2009, 3(4):668-671. doi: 10.1177/193229680900300408.
[13]	CHAIT A, DEN HARTIGH L J. Adipose tissue distribution,inflammation and its metabolic consequences,including diabetes and cardiovascular disease[J]. Front Cardiovasc Med, 2020, 7:22. doi: 10.3389/fcvm.2020.00022.
[14]	WANG Z, NING T, SONG A, et al. Chronic cold exposure enhances glucose oxidation in brown adipose tissue[J]. EMBO Rep, 2020, 21(11):e50085. doi: 10.15252/embr.202050085.
[15]	RAPHAEL A, FRIGER M, BIDERMAN A. Seasonal variations in HbA1c among type 2 diabetes patients on a semi-arid climate between the years 2005-2015[J]. Prim Care Diabetes, 2021, 15(3):502-506. doi: 10.1016/j.pcd.2020.11.013.

季节与气温变化对急性脑梗死患者血糖水平的影响

Effects of seasonal and temperature changes on blood glucose levels in patients with acute cerebral infarction

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