天津医药

• 临床研究 • 上一篇    下一篇

血清淀粉样蛋白A与类风湿关节炎疾病活动度相关性研究

沈忱1,魏蔚2,3,沈忱1,3,刘娜1,3,邢冬红1,3,洪程程1,3,穆云4   

  1. 1. 天津医科大学
    2. 天津医科大学总医院
    3.
    4. 天津市儿童医院
  • 收稿日期:2013-08-27 修回日期:2013-10-28 出版日期:2014-03-15 发布日期:2014-03-15
  • 通讯作者: 沈忱

Study on the Correlation between Serum Amyloid A and Disease Activity in Patients with Rheumatoid Arthritis

  • Received:2013-08-27 Revised:2013-10-28 Published:2014-03-15 Online:2014-03-15
  • Contact: Chen SHEN

PDF (PC)

3113

摘要： 目的 探讨血清淀粉样蛋白A（SAA）与类风湿关节炎（RA）疾病活动度的相关关系及临床意义。方法 收集44例RA患者、35例系统性红斑狼疮（SLE）患者、18例骨关节炎（OA）患者及30例正常对照者血清，采用酶联免疫吸附试验（ELISA）定量检测血清中SAA的浓度，魏氏法检测红细胞沉降率（ESR）,免疫比浊法检测C反应蛋白（CRP）的浓度。检测结果与28关节疾病活动度指数（DAS28）进行相关性分析。 结果 RA患者血清中SAA的水平高于其他三组（P<0.05），血清ESR和CRP的浓度均高于OA和正常对照组，与SLE组相比差异无统计学意义（P>0.05）。SAA、ESR及CRP均与DAS28存在相关关系（r=0.790，P<0.001；r=0.679,P<0.001； r=0.431,P=0.004）。结论 SAA在RA患者体内高表达，与RA疾病活动度指数DAS28显著相关，且比ESR、CRP更为敏感，提示SAA可作为评估RA疾病活动度的新的血清学指标。

关键词: 类风湿关节炎, 血清淀粉样蛋白A, 疾病活动度, 红细胞沉降率, C反应蛋白

Abstract: [Abstract] Objective To investigate the correlation between serum amyloid A and disease activity (DAS28) in patients with rheumatoid arthritis (RA). Methods 44 patients with RA, 35 patients with systemic lupus erythematosus (SLE), 18 patients with osteoarthritis (OA) and 30 healthy people were enrolled in this study. Serum levels of SAA were measured by ELISA. Erythrocyte sedimentation rate (ESR) was measured by the Westergren method. Serum C reactive protein (CRP) concentration was examined by immunonephelometry assay. The correlations between SAA and DAS28、ESR and CRP were assessed, respectively. Results In RA patients, serum levels of SAA was significantly higher (P<0.05) than that in SLE、OA and healthy controls. ESR and CRP levels were both markedly higher than OA and healthy controls, but had no significant difference with SLE. SAA、ESR and CRP levels in serum all had positive correlations with DAS28（r=0.790，P<0.001；r=0.679, P<0.001；r=0.431, P=0.004）. Conclusion Serum SAA levels in RA patients were higher than those in controls and had a positive correlation with RA disease activity, which was more sensitive than ESR and CRP, suggesting that SAA can be a new serological indicator to assess disease activity in RA.

Key words: rheumatoid arthritis, Serum Amyloid A, disease activity, Erythrocyte sedimentation rate, C reactive protein