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β-3肾上腺素受体激动剂治疗膀胱过度活动症的研究进展

邓小林1,陈伟豪2,3,关志忱3,4   

  1. 1. 赣州市人民医院
    2. 汕头大学医学院第一附属医院
    3.
    4. 北京大学深圳医院
  • 收稿日期:2013-05-06 修回日期:2013-10-30 出版日期:2014-03-15 发布日期:2014-03-15
  • 通讯作者: 邓小林

Progress of β3-Adrenoceptor Agonists in the Treatment of the Overactive Bladder

  • Received:2013-05-06 Revised:2013-10-30 Published:2014-03-15 Online:2014-03-15

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摘要： 膀胱过度活动症(overactive bladder,OAB)是一种以尿急症状为特征的症候群,常伴有尿频和夜尿症状,可伴或不伴有急迫性尿失禁。β3肾上腺素能受体激动剂作为治疗OAB的一种新药，不但效果确切，而且安全，耐受性较好，具有广阔的应用前景。本文从作用机制、不良反应、安全性和有效性方面就β3肾上腺素受体激动剂治疗膀胱过度活动症的研究进行综述。

关键词: β-3肾上腺素能受体激动剂, 膀胱过度活动症, 综述

Abstract: Overactive bladder (OAB) is defined as urgency with or without urinary incontinence, usually associated with frequency and nocturia. β3-adrenoceptor (AR) agonists ,as a new effective, safe and well-tolerated class of drug for patients with OAB,appear very promising.we reviewed research data on the mechanism of action, adverse events,pharmacokinetics,safety and efficacy of β3-adrenoceptor agonists in the treatment of the OAB.

Key words: β3-adrenoceptor agonist, overactive bladde, review