天津医药

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IL-17和CRP在慢性阻塞性肺疾病中的作用及相关性

陈凤娟1,沈策2,郑金旭1,卢培1,唐秀忠1,贯剑1   

  1. 1. 上海市第八人民医院
    2. 上海市第六人民医院
  • 收稿日期:2010-08-10 修回日期:2010-12-06 出版日期:2011-06-15 发布日期:2011-06-15
  • 通讯作者: 陈凤娟

The role of Interleukin-17 and CRP in patients with chronic obstructive pulmonary diseases and their correlations

  • Received:2010-08-10 Revised:2010-12-06 Published:2011-06-15 Online:2011-06-15

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摘要： 目的： 通过观察白介素-17（IL-17）、C反应蛋白（CRP）在COPD急性加重期和稳定期患者血清中的表达水平的变化及其相关性，探讨IL-17、CRP在COPD发病机制中的作用，从而为COPD的病情判断和干预治疗提供理论依据。方法： 选择100例COPD急性加重期、100例稳定期患者抽取静脉血标本，采用双抗体ELISA法测定血清中IL-17及CRP水平。并对各研究对象作肺功能检查，计算出FEV1%Pre。结果： COPD急性加重期患者血清IL-17、CRP明显高于稳定期患者(P<0．01)。COPD急性加重期患者血清IL-17与FEV1%Pre呈负相关，相关系数r=-0.437, P<0.05。COPD急性加重期患者血清IL-17与CRP呈正相关，相关系数r=0.582, P<0.05；稳定期患者血清IL-17与CRP呈正相关，相关系数r=0.481, P<0.05.结论： IL-17可能参与COPD的发病，尤其存在急性加重作用。IL-17可替代CRP监测COPD的病情活动。

关键词: 慢性阻塞性肺疾病, 白介素-17, C反应蛋白, 第1秒用力呼气容积

Abstract: Objective By observing the serum level changes and their correlations of Interleukin-17(IL-17) and C reactive protein(CRP) in patients with chronic obstructive pulmonary disease(COPD) at acute exacerbation phase and stable phase，to investigate the role of IL-17 and CRP in pathogenesy of COPD in order to offer evidence for the judgement of illness state and treatment of COPD.Methods The serum levels of IL-17 and CRP were determined in 100 COPD patients at acute exacerbation phase and stable phase by double antibody enzyme-labeled immunosorbent assay (DA-ELISA) . Pulmonary function of all research subjects were tested and calculated for the percentage of FEV1 in prediction value (FEV1%Pre). Results The serum level of IL-17 and CRP in COPD patients at acute exacerbation phase was significantly higher than that at table phase(P<0．01). The serum levels of IL-17 were in negative correlation with FEV1%Pre in COPD patients at acute exacerbation phase, coefficient of correlation r=-0.437, P<0.05；IL-17 were in positive correlation with CRP at acute exacerbation phase, coefficient of correlation r=0.582, P<0.05；at stable phase，coefficient of correlation r=0.481, P<0.05.Conclusions IL-17 might be associated with pathogenesy of COPD,especially play an role of acute exacerbation.It can substitute CRP to monitor the activity of COPD.

Key words: Chronic obstructive pulmonary disease, Interleukin-17, C reactive protein, FEV1