天津医药

• 短篇论著 •    

趋化因子CXCL5启动子区-156G/C基因多态性与2型糖尿病的关系

赵艳茹,刘波,齐曦明,尹福在   

  1. 秦皇岛市第一医院
  • 收稿日期:2011-09-15 修回日期:2012-06-08 出版日期:2012-12-15 发布日期:2012-12-15
  • 通讯作者: 尹福在

The relationship between CXCL5 gene polymorphisms -156G/C (rs352046) and diabetes mellitus in Han minority population in hebei province.

  • Received:2011-09-15 Revised:2012-06-08 Published:2012-12-15 Online:2012-12-15

PDF (PC)

1898

摘要： 【摘要】目的 探讨趋化因子CXCL基因启动子-156位点G/C单核苷酸多态性与中国河北秦皇岛地区人群2型糖尿病的相关性。方法 采用多聚酶链式反应限制性片段长度多态性(PCR-RFLP)方法，检测趋化因子CXCL基因启动子-156位点G/C多态性，其中2型糖尿病患者及210例，对照者171例。结果 趋化因子CXCL5启动子-156G/C多态性（各基因型频率、C等位基因频率）在糖尿病组与对照组的分布差异无统计学意义P＞0.05，C 等位基因与G等位基因比较不增加糖尿病的发病率，OR值为1.214（ 95%CI= 0.859-1.716），G/C+C/C 基因型与 G/G基因型比较不增加糖尿病的发病率，OR值为1.131（95%CI= 0.748-1.710）。结论 中国河北秦皇岛地区人群2型糖尿病组和对照组CXCL5基因型和等位基因分布上差异无统计学意义，本地区人群CXCL5基因多态性可能不是糖尿病发病的危险因素。

关键词: 2型糖尿病, CXCL5基因, 基因多态性, 遗传易感性

Abstract: 【Abstract】Objective To investigate the relationship between the CXCL5 gene –156G/C polymorphism and type 2 diabetes mellitus in Han population of Qinhuangdao region of north China's Hebei Province. Methods The polymorphism of CXCL5 gene promoter region -156G/C was detected by PCR-RFLP method in 210 patients with type 2 diabetes and 171 normal controls. The genotype and allele frequencies distributions were compared between two groups. Results Distribution of genotype and allele of the two groups are not statistically significant（χ2=2.80， p=0.247；χ2=1.029， P=0.310）. The –156G/C polymorphism was not associated with type 2 diabetes，（OR=1.214 95%CI= 0.859-1.716）. Conclusions In Qinhuangdao Area, T2DM group and the control group show no statistically significant difference in the distribution of genotype and allele. Perhaps, CXCL5 genetic polymorphism is not a risk factor for diabetes in Hebei Han minority.

Key words: type 2 diabetes mellitus, CXCL5, gene polymorphisms, genetic susceptibility