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天麻素注射液对急性脑梗死的神经保护作用

王彤宇   

  1. 海洋石油总医院
  • 收稿日期:2010-06-07 修回日期:2010-09-17 出版日期:2011-03-15 发布日期:2011-03-15
  • 通讯作者: 王彤宇

Neurological protection effect of gastrodin injection on acute cerebral infarction

WANG Tong-Yu   

  • Received:2010-06-07 Revised:2010-09-17 Published:2011-03-15 Online:2011-03-15
  • Contact: WANG Tong-Yu

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摘要： 【摘要】目的 评价天麻素注射液对于急性脑梗死患者的治疗效果及神经保护作用。方法 采用单中心病例随机对照研究，分别应用天麻素注射液及低分子右旋糖酐治疗。分别在治疗前、治疗后第3天、第7天检测血清一氧化氮(NO)，一氧化氮合酶(NOS)、超氧化物岐化酶(SOD)及丙二醛(MDA)等含量，同时评价患者神经功能。结果 两组在治疗前NO、NOS、SOD、MDA四个指标比较均无差异；治疗后第3天治疗组NOS水平明显高于对照组(P<0.01)，MDA水平明显低于对照组(P<0.01)；治疗后第7天治疗组NO、NOS、SOD水平明显高于对照组(P<0.05及P<0.01)，MDA水平明显低于对照组(P<0.01)。治疗组NIHSS评分在治疗后第3天及治疗后第7天显著低于对照组(P<0.01)。结论 天麻素可通过影响脑血管内皮细胞分泌血管活性物质—一氧化氮及其合成酶，和抑制脂质过氧化反应，改变血清氧化/还原物质比值，从而达到保护神经细胞的作用，同时明显改善患者临床神经功能。

关键词: 脑梗死, 天麻素, 神经保护

Abstract: Abstract Objective To evaluate the effect of the gastrodin injection on the patients of acute cerebral infarction.Methods 146 cases of cerebral infarction were divided into trial group and control group.Serum superoxide(SOD)、malondialdehy(MDA)、nitric oxide(NO)and NO-synthase were assessed.The neurologic function at 1,3 and 7 days were assessed. Results The levels of above four indexes were not different between two groups before medication. The level of NOS in trial group was higher than control group in 3th day,but the level of MDA in trial group was lower than control group in 3th day. The levels of NOS、NO and SOD in trial group were higher than control group in 7th day,but the level of MDA in trial group was lower than control group.The neurologic function in trial group was better than control group.in 3th and 7th day.Conlusion Gastrodin injection piay the roie of protection on nerve cells and can ameliorate nerve function.

Key words: cerebral infarction, gastrodin, nerve protection