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血浆致动脉粥样硬化指数与冠心病及其危险因素的相关性分析

张煜1,李广平2,李立丰3,陈艳3,徐颖3   

  1. 1. 天津医科大学第二医院心内科
    2. 天津医科大学第二医院心脏科
    3. 天津医科大学第二医院
  • 收稿日期:2010-08-24 修回日期:2010-12-20 出版日期:2011-04-15 发布日期:2011-04-15
  • 通讯作者: 张煜

Analysis on the correlation between atherogenic index of plasma and coronary heart disease as well as risk factors

  • Received:2010-08-24 Revised:2010-12-20 Published:2011-04-15 Online:2011-04-15
  • Contact: yu ZHANG

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摘要： 【摘要】 目的:分析血浆致动脉粥样硬化指数（AIP）与冠状动脉粥样硬化性心脏病（冠心病）及其危险因素的相关性。方法:连续入选天津市大港区油田常住人口348例，根据体检结果分为无冠心病和冠心病组，对两组间AIP和已知冠心病危险因素进行比较，并分析AIP与冠心病及其常见危险因素的相关性。结果:冠心病组的年龄、男性比重、吸烟率、高血压患病率、糖尿病患病率、既往脑卒中患病率、BMI、收缩压、舒张压、空腹血糖、尿酸及静息心率均显著高于对照组， AIP、低密度脂蛋白(LDL-C)、总胆固醇(TC)、ln（TC）均显著高于对照组，高密度脂蛋白(HDL-C)冠心病组显著低于对照组（P<0.05）。总胆红素、ln（ALT）、ln（AST）两组间对比无统计学差异。AIP与年龄、冠心病、高血压、脑卒中、吸烟、BMI、收缩压、舒张压、空腹血糖、TC、ln（TC）、LDL-C、尿酸呈正相关；与HDL-C呈负相关；与静息心率、糖尿病无明显相关。舒张压、TC、LDL-C、HDL-C均进入线性回归方程（P<0.05）。结论：AIP与冠心病及其危险因素密切相关， AIP的不同水平结合传统的冠心病危险因素能够更好的预测冠心病发生的可能性，进而为冠心病的预防及诊疗提供更多信息及帮助。

关键词: 血浆致动脉粥样硬化指数(AIP), 冠心病, 危险因素

Abstract: 【Abstract】 Objective : To analyze the correlation between atherogenic index of plasma (AIP) and coronary heart disease (CHD), as well as its risk factors. Methods: We selected 348 residents in Dagang district, Tianjin. All participants were divided into CHD and control group according to the clinical and laboratory examinations. We compared the levels of plasma TG, HDL-C, LDL-C, AIP and other risk factors of CHD between these two groups and analyzed of the correlation between the presence of CHD, the risk factors of CHD and AIP respectively. Results: we found that the percentile of male, hypertension, diabetes mellitus (DM), smoking, stoke were significant higher in CHD than that of control group （P<0.05）. Compared with control group, Age, BMI, systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood glucose, TG, ln （TC）, LDL-C, uric acid, AIP, HR were higher, and the level of HDL-C were lower in CHD group significantly （P<0.05）. Total bilirubin, ln （ALT）, ln（AST） had no significant differences between two groups. There were positive correlations among AIP and the percentile of hypertension, smoking, stoke, age, BMI, SBP, DBP, fasting blood glucose, TG, ln （TC）, LDL-C and uric acid. But there were negative correlations between AIP and HDL-C. SBP, DBP, TG, HDL-C and LDL-C enter in the regression equation (P<0.05). Conclusion: The level of AIP is strongly correlated with the CHD and the risk factors. Combined with traditional CHD risk factors, it strongly predicts the presence of CHD, and can provide more information for the prevention, diagnosis and treatment of CHD.

Key words: Atherogenic index of plasma (AIP), Coronary heart disease, Risk factors