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益气活血法对兔肺心病模型心脏形态影响的实验研究

沈燕华1,欧敏2   

  1. 1. 北京市海军总医院超声诊断科
    2. 海军总医院
  • 收稿日期:2010-03-02 修回日期:2010-05-06 出版日期:2010-11-15 发布日期:2010-11-15
  • 通讯作者: 沈燕华

Effect study of Yiqihuoxue treatment on cardiac morphology in rabbits with pulmonary heart disease

  • Received:2010-03-02 Revised:2010-05-06 Published:2010-11-15 Online:2010-11-15
  • Contact: SHEN Yan-hua

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摘要： 目的：研究益气活血法治疗兔肺心病模型的心脏形态变化。方法：将32只健康日本大耳兔随机分为4组，即正常组、模型组、中药治疗组及卡托普利组。予其中模型组、中药治疗组、卡托普利组三氯化铁复制肺心病模型，对中药治疗组、卡托普利组灌胃相应药物各20天，观察造模前、造模后、治疗后家兔全身状况，应用超声心动图观察心脏形态变化。结果：造模后家兔的呼吸频率加快，右室及肺动脉内径增大，右室壁增厚，三尖瓣及肺动脉血流速度降低，超声各参数差异均具有统计学意义(P <0.05或P <0.01)。治疗后，中药治疗组的体重增加及呼吸改善均好于卡托普利组，中药治疗组的右室内径明显减小，差异具有统计学意义(P <0.05)。结论：应用益气活血法治疗兔肺心病模型，可以有效缓解症状，减小右心室内径，降低肺动脉压力。

关键词: 肺源性心脏病, 肺动脉高压, 兔, 超声心动图, 右室

Abstract: Objective: To observe the changes in heart morphology of Yiqihuoxue treatment in Rabbits with pulmonary heart disease . Methods: We had randomly divided 32 healthy Japanese white rabbits into 4 groups, Normal Group(NG), Model Group(MG)，Chinese Medicine Group(CMG) and Captopril Group(CG). Three groups of above mentioned, MG，CMG and CG ,had been given a single dose of Fecl3 induced the model of pulmonary heart disease . Then after that, we treated the 2 groups of them, CMG and CG, respectively 20 days. We had observed and recorded the data of the general conditions, and detected all above groups by echocardiography before & after modeling, and after treating. Results: After modeling, there emerged some value of statistical difference on the field of echocardiographic parameters, such as right ventricular diameter（RVD）, pulmonary artery diameter(PAD), the thickness of right ventricular anterior wall(RVAW), tricuspid valve (TV)and pulmonary artery(PV) blood flow velocity(P <0.05 or P <0.01). After treating，We found the weight and breathe of CMG had been improved better than the CG.. We also observed the right ventricular diameter (RVD) was significantly less in the CMG than the other groups(P <0.05). Conclusion: Yiqihuoxue treatment can be effectively alleviate the symptoms，reduce the right ventricular diameter (RVD) and lower pulmonary artery pressure.

Key words: Pulmonary heart disease, pulmonary hypertension, rabbit, echocardiography, right ventricular