天津医药

天津医药 ›› 2015, Vol. 43 ›› Issue (3): 296-299.doi: 10.11958/j.issn.0253-9896.2015.03.020

• 专题研究·心血管疾病 • 上一篇    下一篇

血清钾水平与冠状动脉病变程度的相关性研究

牛雪凝， 李广平△   

  1. 天津医科大学第二医院心脏科、 天津心脏病学研究所 （邮编 300211）
  • 收稿日期:2014-08-07 修回日期:2014-10-27 出版日期:2015-03-15 发布日期:2015-03-15
  • 通讯作者: 李广平 E-mail:niuxuening@163.com
  • 作者简介:牛雪凝 （1989）， 女， 硕士在读， 主要从事冠心病基础与临床研究

Study of correlation between serum potassium concentration and the severity of coronary artery disease#br#

NIU Xuening, LI Guangping△   

  1. Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin 300211, China
  • Received:2014-08-07 Revised:2014-10-27 Published:2015-03-15 Online:2015-03-15
  • Contact: LI Guangping E-mail:niuxuening@163.com

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摘要： 目的 探讨血清钾水平与冠状动脉病变程度的关联性。方法 纳入行冠状动脉造影者 246 例， 按病变累及主要冠状动脉支数分为对照组 （0 只病变， 81 例）、 单支病变组 （43 例）、 双支病变组 （46 例） 和三支病变组 （76 例），按照血清钾水平分为低水平血清钾组 （低钾组， K+＜4.0 mmol/L） 99 例和高水平血清钾组 （高钾组， K+≥4.0 mmol/L） 147例； 采用 Gensini 评分定量评估各支冠状动脉的狭窄程度； 比较各组的临床资料， 分析 Gensini 评分与各临床指标的相关性， 采用 Logistic 回归分析冠心病的危险因素。结果 （1） 三支病变组的年龄、 男性、 吸烟、 2 型糖尿病、 高血压患者比例均高于对照组， 三支病变组的血清钾浓度低于对照组和单支病变组（mmol/L:3.97±0.37 vs 4.11±0.33 vs 4.13±0.41）， 差异均有统计学意义； 双支病变组的年龄、 男性、 高血压病患者比例高于对照组。单支病变组的男性和高血压患者比例高于对照组。各组 Gensini 评分： 三支病变组＞双支病变组＞单支病变组＞对照组（均 P＜0.05）。（2）低钾组 Gensini 评分[36 （8， 94） ]高于高钾组[16 （0， 56） ]， 差异有统计学意义。（3） 血清钾与 Gensini 评分呈负相关 （r=-0.206，P=0.001）。（4） 高龄、 男性、 血清钾低水平、 合并有糖尿病和高血压为冠心病的危险因素。结论 血清钾水平与冠状动脉病变严重程度呈负相关， 血清钾低水平为冠心病的独立危险因素。

关键词: 钾, 冠状动脉病变, 危险因素, 动脉粥样硬化, Gensini 评分

Abstract: Objective To determine the association between serum potassium level and the severity of coronary artery atherosclerosis. Methods A total of 246 patients underwent coronary artery angiography were included into this study, and were divided into four groups according to the involved main coronary artery: control group (0 diseased vessel, n=81), one diseased vessel group (n=43), double diseased vessel group (n=46) and three diseased vessel group (n=76). Patients were also divided into low potassium group (K +<4.0 mmol/L, n=99) and high potassium group (K +≥4.0 mmol/L, n=147) according to the levels of serum potassium. The severity of coronary stenosis was quantitated by Gensini score system. The clinical data were compared between groups. The relationship between Gensini score system and clinical information was analyzed. The multiple regression method was used to analyse the risk factors of coronary heart disease (CHD). Results (1) There were higher percentages of elders, male, smoking, diabetes mellitus and hypertension patients in three diseased vessel group than those of control group. The serum potassium level was significantly lower in three diseased vessel group (3.97 mmol/L±0.37 mmol/L) than that of control group (4.11 mmol/L±0.33 mmol/L) and one diseased vessel group (4.13 mmol/L±0.41 mmol/L). There were higher percentages of elders, male and hypertension patients in double diseased vessel group than those of control group. The percentages of male and hypertension patients were higher in one diseased vessel group than those of control group. The Gensini scores were three diseased vessel group > double diseased vessel group > one diseased vessel group > control group (P < 0.05). (2) There was a significantly higher Gensini score in low potassium group [36(8, 94)] than that of high potassium group [16（0， 56)]. (3) There was significant negative correlation between serum potassium level and Gensini score (r=-0.206, P=0.001). (4) It was found that age, male, the low level of serum potassium, diabetes mellitus and hypertension were independent risk factors of CHD. Conclusion The serum potassium level is negatively correlated with the severity of CHD. The low level of serum potassium is an independent risk factor of CHD.

Key words: serum potassium, coronary atherosclerotic lesion, risk factors, atherosclerosis, Gensini&rsquo, s score