天津医药

天津医药 ›› 2015, Vol. 43 ›› Issue (12): 1453-1455.doi: 10.11958/j.issn.0253-9896.2015.12.029

• 药物临床观察 • 上一篇    下一篇

氯沙坦钾联合辛伐他汀对糖尿病腹膜透析患者氧化应激的影响

刘华，刘翠兰，程锦绣，陆继芳，刘圣君   

  1. 河北北方学院附属第一医院肾内科（邮编075000）
  • 收稿日期:2015-03-09 修回日期:2015-07-10 出版日期:2015-12-15 发布日期:2015-12-11
  • 作者简介:刘华（1971），女，副主任医师，副教授，学士，主要从事临床肾脏病研究

The effects of losartan potassium and simvastatin combination therapy on oxidative stress indicators in diabetic patients on peritoneal dialysis

LIU Hua, LIU Cuilan, CHENG Jinxiu, LU Jifang, LIU Shengjun   

  1. Department of Nephrology, the First Affiliated Hospital of Heibei North University,Zhangjiakou 075000，China
  • Received:2015-03-09 Revised:2015-07-10 Published:2015-12-15 Online:2015-12-11

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摘要： 目的对比观察期为12 周的氯沙坦钾与辛伐他汀联合治疗对糖尿病腹膜透析患者氧化应激指标的影响。方法收集2 型糖尿病合并糖尿病肾病终末期新进入持续不卧床腹膜透析(CAPD)的患者80 例，随机分为2 组：对照组40 例腹膜透析及常规治疗；治疗组40 例在对照组基础上给予氯沙坦钾50 mg，1 次/d，辛伐他汀分散片 20 mg，每晚1 次。对比2 组透析前及透析12 周后糖化血红蛋白（HbA1C）、胰岛素用量、超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-PX）、丙二醛(MDA)、同型半胱氨酸（Hcy）等指标变化。结果2 组HbA1C 治疗前后及组间差异均无统计学意义（P＞0.05），2 组在CAPD 治疗后所用胰岛素剂量均较透析前增加，其中治疗组低于对照组（P＜ 0.05）；透析后，治疗组SOD、GSH-PX 表达水平均高于治疗前和对照组，MDA 和Hcy 均低于治疗前和对照组（P＜ 0.05）；对照组GSH-PX 水平低于透析前，MDA 和Hcy 则高于治疗前（P＜0.05）。结论氯沙坦钾联合辛伐他汀对糖尿病腹膜透析患者氧化应激指标的改善疗效确切。

关键词: 腹膜透析, 持续不卧床, 糖尿病肾病, 氧化性应激, 药物疗法, 联合, 氯沙坦钾, 辛伐他汀

Abstract: Objective To explore the effects of losartan potassium and simvastatin combination therapy on oxidative stress indicators in diabetic patients on peritoneal dialysis through 12 weeks observation. Methods Diabetic patients with end-stage nephropathy (n=80) who were treated with continuous ambulatory peritoneal dialysis were randomly divided into two groups: control group who received routine treatment (n= 40), treatment group who were given losartan potassium 50 mg, once per day and simvastatin 20 mg, once every night (n=40). HbA1C, Insulin dosage, Oxidative stress indicators（SOD, GSH-PX, MDA and Hcy）were compared between two groups before and after peritoneal dialysis. Results There was no significant difference of HbA1C between the 2 groups before and after treatment（P＞0.05）. The insulin doses increased be⁃ fore dialysis in both groups after CAPD treatment. It is lower in the treatment group than that in the control group (P＜0.05). The expression levels of GSH-PX and SOD in treatment group were higher while the expressions of Hcy and MDA were lower after treatment. The expressions of GSH-PX and SOD were higher while the expressions of Hcy and MDA were lower in treat⁃ ment group than those in control group when comparing the same time point（P＜0.05）. GSH-PX expression level was lower while the expressions of MDA and Hcy were higher after dialysis than those before dialysis in control group (P＜0.05). Con⁃ clusion Losartan potassium combined with simvastatin treatment can improve curative effect and oxidative stress indicators in diabetic patients on peritoneal dialysis.

Key words: peritoneal dialysis, continuous ambulatory, diabetic nephropathies, oxidative stress, drug therapy, combina? tion, Losartan potassium, Simvastatin