天津医药

天津医药 ›› 2015, Vol. 43 ›› Issue (12): 1456-1459.doi: 10.11958/j.issn.0253-9896.2015.12.030

• 综述 • 上一篇    下一篇

L-型氨基酸转运体1 在肿瘤诊断和治疗中的研究进展

董艳1,2，武卫党2，慈小燕2，高晶2，曾勇2，伊秀林2△   

  1. 1天津医科大学药学院（邮编300070）；2天津药物研究院有限公司释药技术与药代动力学国家重点实验室
  • 收稿日期:2015-05-18 修回日期:2015-06-19 出版日期:2015-12-15 发布日期:2015-12-11
  • 通讯作者: △审校者和通讯作者E-mail:yixl@tjipr.com E-mail:dongyan0902@163.com
  • 作者简介:董艳（1990），女，硕士在读，主要从事药物代谢动力学研究
  • 基金资助:
    国家“重大新药创制”科技重大专项“新药临床前药物代谢动力学技术平台建设”（2012ZX09304002）

Current research of L-amino acid transporter 1 in tumor diagnosis and treatment

DONG Yan1,2,WU Weidang2,CI Xiaoyan2,GAO Jing2,ZENG Yong2,YI Xiulin2△   

  1. 1 College of Pharmacy,Tianjin Medical University, Tianjin 300070,China;2 State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research
  • Received:2015-05-18 Revised:2015-06-19 Published:2015-12-15 Online:2015-12-11
  • Contact: △Reviser and Corresponding Author E-mail:yixl@ tjipr.com E-mail:dongyan0902@163.com

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摘要： L-型氨基酸转运体1（LAT1）是L-型氨基酸转运蛋白家族的一个成员，它是由两条多肽链通过二硫键形成的异二聚体，也是异二聚体氨基酸转运体SLC7 亚家族的重要成员。LAT1 的主要功能是介导一些分子中含有苯环或者支链的、分子质量较大的、体液环境中酸碱性呈中性的氨基酸（L-亮氨酸、L-甲硫氨酸和L-苯丙氨酸等）及其类似物（美法仑、多巴和甲状腺素等）的跨膜转运，其跨膜转运方式为不依赖Na+和ATP 的协助扩散。LAT1 转运体在许多肿瘤细胞中有特异性的高表达，且其表达程度与临床上肿瘤的分期情况及治疗预后有密切的联系。LAT1 不仅被证明在肿瘤诊断中具有重要意义，也是一个潜在的肿瘤治疗靶点。本文对LAT1 的结构和转运特点进行了阐述，并总结了LAT1 在肿瘤诊断和治疗中的最新研究进展。

关键词: 氨基酸转运系统, 肿瘤, 综述, L-型氨基酸转运体1, 肿瘤诊断, 肿瘤治疗

Abstract: L-amino acid transporter 1 ( LAT1) is a member of L-amino transporter family and an important heterodi⁃ meric amino acid transporter that belongs to subfamily of SLC7. LAT1 mainly mediates trans-membrane transportation of those neutral amino acids that had cyclobenzene or long side chains with high molecular mass such as L-Leu, L-Met and LPhe as well as some amino acid analogues such as melphalan, L-DOPA and thyroxine in a Na+ and ATP-independent diffu⁃ sion. As LAT1 was abnormally overexpressed in various transformed cell lines, it might be related with tumor stage and prog⁃ nosis. It is not only a biomarker that specifically expressed in some tumor cells but also plays an important role in tumor diag⁃ nosis and therapy. Here we demonstrate the structure of LAT1 and its mechanism in transport peculiarity. We also reviewed the development of LAT1 in tumor diagnosis and treatment.

Key words: amino acid transport systems, neoplasms, review, L-type amino acid transporter, tumor diogonsis, tumor therapy