天津医药

天津医药 ›› 2016, Vol. 44 ›› Issue (8): 959-962.doi: 10.11958/20160120

• 专题研究-心血管 • 上一篇    下一篇

踝肱指数的变化与新发不良心脑血管事件的关系

周皖舒， 彭年春△， 时立新， 张巧， 胡颖， 徐淑静， 张淼， 张松   

  1. 贵州医科大学附属医院内分泌代谢病科 （邮编550004）
  • 收稿日期:2016-03-07 修回日期:2016-05-10 出版日期:2016-08-15 发布日期:2016-08-22
  • 通讯作者: 周皖舒 （1990）， 女， 硕士在读， 主要从事内分泌代谢疾病研究 E-mail:1025066337@qq.com
  • 作者简介:周皖舒 （1990）， 女， 硕士在读， 主要从事内分泌代谢疾病研究
  • 基金资助:
    中华医学会临床医学科研专项资金项目 （12020130273）

Analysis of the correlation between the change of ABI and new adverse cardiovascular events

ZHOU Wanshu, PENG Nianchun△, SHI Lixin, ZHANG Qiao, HU Ying, XU Shujing, ZHANG Miao, ZHANG Song   

  1. Endocrine & Metabolic Diseases Unit, The Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China
  • Received:2016-03-07 Revised:2016-05-10 Published:2016-08-15 Online:2016-08-22

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摘要： 摘要： 目的 探讨踝肱指数 （ABI） 的变化与新发不良心脑血管事件的关系。方法 2011 年 5 月—8 月， 采用整群抽样法对贵阳市云岩区 4 160 例 40 岁及以上常住居民进行基线调查， 测定 ABI 并收集体格检查、 血生化检测及病史资料， 于 2014 年 7 月—12 月对该人群进行随访调查， 平均随访 （39.29±1.47） 个月。根据随访与入选时相比 ABI 变化情况 （ΔABI） 将入选人群分为 3 组： ΔABI＞0.15 组， -0.15≤ΔABI≤0.15 组， ΔABI＜-0.15 组。比较 3 组人群在随访期间新发不良心脑血管事件情况， 并分析影响不良心脑血管事件的危险因素。结果 3 年后共完成随访 3 220 例，随访完成率为 77.4%。3 220 例在随访期间共新发不良心脑血管事件 82 例 （2.5%）。其中， ΔABI＜-0.15 组不良心脑血管事件发生率较-0.15≤ΔABI≤0.15 组升高 （8.3% vs. 2.4%， P＜0.016 7）。Logistic 回归分析表明， 年龄高、 高血压史和ΔABI＜-0.15均为不良心脑血管事件的危险因素， 运动是保护因素。结论 ΔABI＜-0.15者不良心脑血管事件的发生风险增加， ΔABI可作为不良心脑血管事件的监测手段， 对判断不良心脑血管事件的发生有一定的预测价值。

关键词: 心脑血管事件, 踝肱指数, 危险因素

Abstract: Abstract: Objective To investigate the relationship between changes of ankle brachial index (ABI) and adverse cardiovascular events. Methods Baseline survey was conducted in 4 160 forty-year-old or older citizens living in Yunyan District of Guiyang City from May to August of 2011, which was in the way of cluster sampling to obtain their ABI and to collect information related to physical and blood biochemical examination and disease history. These citizens were conducted a follow-up survey for (39.29±1.47) months from July to December of 2014. Based on the change of ABI (ΔABI) from initial survey to follow-up survey, participants were subsequently divided into three groups: ΔABI＞0.15 group, -0.15 ≤ ΔABI ≤ 0.15 group and ΔABI＜-0.15 group. The adverse cardiovascular events during follow-up survey were compared between three groups. The risk factors affecting the adverse cardiovascular events were analyzed. Results Follow-up surveys were completed in 3 220 citizens in 3 years. The follow- up rate was 77.4% . Eighty- two new cases (2.5% ) of adverse cardiovascular events were found in 3 220 cases in follow-up. The incidence rates of adverse cardiovascular events were higher in ΔABI＜-0.15 group compared with those of -0.15 ≤ ΔABI ≤ 0.15 group (8.3% vs. 2.4%, P＜0.016 7). Logistic regression analysis indicated that age, hypertension history, and ΔABI＜-0.15 were risk factors for adverse cardiovascular events. Exercise was the protective factor for adverse cardiovascular events. Conclusion Subjects with ΔABI＜-0.15 are at high risk for adverse cardiovascular events. The ΔABI can be used as a means of monitoring of adverse cardiovascular event, which provides certain forecast value for determining the possibility of adverse cardiovascular event.

Key words: cardiovascular events, ankle brachial index, risk factors