天津医药

天津医药 ›› 2016, Vol. 44 ›› Issue (9): 1143-1146.doi: 10.11958/20160027

• 药物临床观察 • 上一篇    下一篇

黄连素对精神分裂症患者胰岛素抵抗与细胞因子的影响

李建功 1,2， 赵永萍 2， 刘莹 2， 仇玉莹 2， 李美娟 1,2， 贾琼 1， 张静 1， 李洁 2△   

  1. 1 天津医科大学精神病与精神卫生专业（邮编 300070）；2天津市安定医院八科
  • 收稿日期:2016-01-22 修回日期:2016-04-12 出版日期:2016-09-15 发布日期:2016-09-28
  • 通讯作者: 李洁 E-mail:tjlijie3827@163.com
  • 作者简介:李建功（1983）， 男， 住院医师， 硕士在读， 主要从事生物精神病学研究
  • 基金资助:
    天津市安定医院院级课题基金资助（1507）

The impact of berberine on insulin resistance and cytokines in patients with schizophrenia

LI Jiangong1.2, ZHAO Yongping2, LIU Ying2, QIU Yuying2, LI Meijuan1.2, JIA Qiong1, ZHANG Jing1, LI Jie2△   

  1. 1 Department of Psychiatry, Tianjin Medical University, Tianjin 300070, China; 2 Department of Psychiatry, Tianjin Anding Hospital
  • Received:2016-01-22 Revised:2016-04-12 Published:2016-09-15 Online:2016-09-28
  • Contact: LI Jie E-mail:tjlijie3827@163.com

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摘要： 目的 探讨黄连素对利培酮单药治疗的精神分裂症患者胰岛素抵抗与血清细胞因子水平的影响。 方法 将 64 例利培酮单药治疗的精神分裂症患者随机分为研究组（合并黄连素治疗）31 例和对照组（合并安慰剂治疗）33 例， 测定 2 组患者治疗前及治疗 12 周后的空腹血糖（FBG）、空腹胰岛素（Fins）， 采用稳态模型公式计算胰岛素抵抗指数（HOMA-IR）。 采用酶联免疫吸附法测定血清白细胞介素（IL）-1β、IL-6、肿瘤坏死因子（TNF）-α 水平。 结果 研究组治疗后的 FBG、Fins、HOMA-IR、IL-1β、IL-6、TNF-α 水平较自身治疗前和对照组治疗后均显著降低（P < 0.05）； 而对照组治疗后较治疗前 FBG 水平则显著升高（P < 0.01）， IL-1β、IL-6、TNF-α 水平降低（P < 0.01）， Fins、HOMA-IR 水平无明显变化（P > 0.05）。 研究组患者 HOMA-IR 与血清 IL-1β、IL-6、TNF-α 均呈正相关（r 分别为 0.316、 0.351 及 0.401， P < 0.01）。 结论 黄连素能显著降低利培酮单药治疗的精神分裂症患者 FBG、 Fins、 HOMA-IR、IL-1β、IL-6、TNF-α 水平， 且 HOMA-IR 水平与 IL-1β、IL-6、TNF-α 密切相关。

关键词: 精神分裂症, 胰岛素, 血糖, 白细胞介素 1β, 肿瘤坏死因子 α, 黄连素, 胰岛素抵抗

Abstract: Objective To explore the impact of berberine on serum levels of insulin resistance and cytokines in schizophrenia patients treated with risperidone. Methods Sixty-four schizophrenia patients treated with risperidone were randomized to berberine group (n=31) and control group (n=33). The fasting plasma blood glucose (FBG) and fasting insulin (Fins) were detected before and after treatment in two groups. The homeostasis model assessment for insulin resistance (HOMA-IR) was calculated. The serum levels of interleukin (IL)- 1β, IL- 6, tumor necrosis factor-alpha (TNF- α) were evaluated by enzyme linked immunosorbent assay before and after the treatment. Results Compared with control group and pre-treatment group, the levels of FBG, Fins, HOMA-IR, IL- 1β, IL- 6 and TNF- α were significantly decreased after treatment in berberine group (P < 0.05). The FBG level was significantly higher, the levels of IL-1β, IL-6 and TNF-α were significantly lower, after treatment in control group (P < 0.01). There were no significant changes in Fins and HOMA-IR after treatment (P > 0.05). There was positive correlation between HOMA-IR and IL- 1β, IL-6 and TNF-α in berberine group (r=0.316, 0.351 and 0.401, P < 0.01). Conclusion Berberine can significantly decrease FBG, Fins, HOMA-IR, IL1β, IL-6 and TNF-α levels in schizophrenia patients treated with risperidone. The HOMA-IR level is closely correlated with IL-1β, IL-6 and TNF-α levels.

Key words: schizophrenia, insulin, blood glucose, interleukin-1beta, tumor necrosis factor-alpha, berberine, insulin resistance