天津医药

天津医药 ›› 2016, Vol. 44 ›› Issue (9): 1139-1142.doi: 10.11958/20150413

• 药物临床观察 • 上一篇    下一篇

比索洛尔联合瑞舒伐他汀对冠状动脉慢血流患者内皮功能及炎症的影响

黄敏1,夏中华1,谢福生2,周天天3   

  1. 桂林医学院第二附属医院心血管内科（邮编 541100）
  • 收稿日期:2015-12-22 修回日期:2016-04-13 出版日期:2016-09-15 发布日期:2016-09-28
  • 通讯作者: 夏中华 E-mail:237679075@qq.com
  • 作者简介:黄敏（1989）， 男， 硕士在读， 主要从事急性冠脉综合征的诊断与治疗研究
  • 基金资助:
    桂林市科学研究与技术开发计划

Effects of bisoprolol combined with rosuvastatin on endothelial function and inflammation in patients with coronary slow flow#br# #br#

HUANG Min, XIA Zhonghua△, XIE Fusheng, ZHOU Tiantian   

  1. Department of Cardiovascular Medicine, the Second Affiliated Hospital of Medical College, Guilin Medical University, Guilin 541100, China
  • Received:2015-12-22 Revised:2016-04-13 Published:2016-09-15 Online:2016-09-28
  • Contact: XIA Zhonghua E-mail:237679075@qq.com

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摘要： 目的 研究比索洛尔联合瑞舒伐他汀对冠状动脉慢血流（CSF）患者内皮功能和炎症的影响。 方法 选取 2014 年 8 月—2015 年 10 月收治的 90 例 CSF 患者， 按随机数字表法分为对照组、他汀组和联合组， 每组 30 例。 对照组给予常规药物治疗（拜阿司匹林肠溶片 100 mg/d 和单硝酸异山梨酯缓释片 60 mg/d）， 他汀组采用常规治疗加瑞舒伐他汀 10 mg/d， 联合组在他汀组的基础上加用比索洛尔 5 mg/d。 分别检测治疗前和治疗 8 周后患者血清一氧化氮（NO）、内皮素-1（ET-1）、超敏 C 反应蛋白（hs-CRP）、白细胞介素-6（IL-6）水平， 同时评价患者心绞痛的改善情况。 结果 经过 8 周治疗后， 联合组和他汀组患者较治疗前 NO 水平升高， ET-1、hs-CRP、IL-6 水平降低（P＜ 0.05）；治疗后对照组、他汀组和联合组 NO 水平依次升高， ET-1、hs-CRP、IL-6 水平均依次降低， 组间多重比较差异均有统计学意义（P＜ 0.05）。 联合组患者心绞痛的有效率（90.0%）高于对照组（56.7%）， 但与他汀组（83.3%）相比差异无统计学意义。 结论 比索洛尔联合瑞舒伐他汀可改善 CSF 患者血管内皮功能并具有抗炎特性。

关键词: 冠状动脉慢血流, 比索洛尔, 瑞舒伐他汀, 内皮, 血管, 炎症, 一氧化氮, 内皮素-1, 高敏 C 反应蛋白, 白细胞介素 6

Abstract: Objective To investigate the effects of bisoprolol combined with rosuvastatin on endothelial function and inflammation in patients with coronary slow flow (CSF). Methods Ninety CSF patients treated from August 2014 to October 2015 were randomly divided into control group, statin group and combined group, thirty cases in each group. The control group was given conventional therapy (aspirin 100 mg/d and isosorbide mononitrate 60 mg/d), statin group was given rosuvastatin 10 mg/d on the basic of control group, while the combined group was given bisoprolol 5 mg/d on the basic therapy of statin group. The serum concentrations of nitric oxide (NO), endothelin- 1(ET- 1), high-sensitivity c-reactive protein (hs-CRP) and interleukin-6 (IL-6) were detected before treatment and 8 weeks after treatment. The improvement of patients with angina pectoris was evaluated. Results After eight- week treatment, the NO levels were significantly increased in combined group and statin group, while the ET-1, hs-CRP and IL-6 levels were significantly decreased than those before the treatment (P＜ 0.05). At the same time, comparing with the statin group and control group, the NO level was increased in combined group (P＜ 0.05), while the ET-1, hs-CRP, and IL-6 levels decreased significantly (P＜ 0.05). There were significant differences in the effective rates between the combined group (90.0%) and the statin group (83.3%), which were higher than those in control group (56.7% ). Conclusion Bisoprolol combined with rosuvastatin can improve the endothelial function and anti-inflammatory in the treatment of CSF.

Key words: coronary slow flow, bisoprolol, rosuvastatin, endothelium, vascular, inflammation, nitric oxide, endothelin- 1, hypersensitive C-reactive protein, interleukin-6