天津医药

天津医药 ›› 2017, Vol. 45 ›› Issue (1): 43-46.doi: 10.11958/20161228

• 临床研究 • 上一篇    下一篇

川崎病患者急性期血清降钙素原水平的变化和临床意义 #br# #br#

刘力 1,2， 魏蔚 3， 胡坚 2△ #br# #br#   

  1. 1 天津医科大学研究生院 （邮编 300070）； 2 天津市儿童医院免疫科； 3 天津医科大学总医院风湿免疫科

  • 收稿日期:2016-10-27 修回日期:2016-12-05 出版日期:2017-01-15 发布日期:2017-01-15

Clinical significance of serum procalcitotin in children with Kawasaki disease at acute stage #br# #br#

LIU Li1,2， WEI Wei 3， HU Jian2△ #br# #br#   

  1. 1 Graduate School of Tianjin Medical University, Tianjin 300070, China; 2 Department of Immunology, Tianjin Children’ s
    Hospital; 3 Department of Rheumatology and Immunology, Tianjin Medical University General Hospital

  • Received:2016-10-27 Revised:2016-12-05 Published:2017-01-15 Online:2017-01-15

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摘要： 摘要： 目的 评价川崎病（KD）患者急性期血清降钙素原（PCT）水平的变化和临床意义。方法 回顾分析 120 例 KD 患儿急性期血清 PCT 水平和治疗前后的变化。根据超声心动图结果， 将全部患儿分为冠状动脉损伤 （CAL） 组 和无冠状动脉损伤（NCAL）组； 根据是否存在胃肠道症状（A 组： 是， B 组： 否）组及是否存在肝功能异常（C 组： 是， D 组： 否）组。比较各分组之间 PCT 水平的差异。结果 急性期血清 PCT 在治疗前高于正常值的患儿共有 56 例 （46.67%）， 治疗后血清 PCT 明显下降， 差异有统计学意义（P＜0.05）。120 例 KD 患儿中 CAL 组共 31 例， 其 PCT 升 高率（38.71%）与 NCAL 组（49.44%）差异无统计学意义， CAL 组与 NCAL 组血清 PCT 值差异亦无统计学意义。CAL 组患儿 C 反应蛋白水平高于 NCAL 组。120 例 KD 患儿中有胃肠道症状者共 35 例， 其 PCT 升高率 （62.86%） 与无胃 肠道症状组（40.00%）差异有统计学意义（P＜0.05）， 此 2 组间血清 PCT 水平差异无统计学意义。120 例 KD 患儿中 有肝功能异常者共 42 例， 其 PCT 升高率 （52.38%） 与无肝功能异常组 （43.59%） 差异无统计学意义， 血清 PCT 值在此 2 组间差异亦无统计学意义。结论 PCT 可以反映 KD 患者急性期的炎症状态， 其水平升高不能预测 CAL 和肝功能 异常的发生， 但与胃肠道症状的出现或许有关

关键词: 黏膜皮肤淋巴结综合征, 降钙素, 冠状动脉疾病, 胃肠疾病, 肝疾病, 川崎病, 降钙素原

Abstract:

Abstract: Objective To investigate the changes and clinical significance of serum procalcitonin (PCT) level in
children with acute phase of Kawasaki disease (KD). Methods The serum PCT levels and their changes before and after
the treatment in 120 children with KD at acute phase were retrospectively analyzed. According to the results of ultrasonic
echocardiography, all children were divided into coronary artery damage (CAL) group and no coronary artery lesion (NCAL)
group. According to the presence of gastrointestinal symptoms, patients were divided into two groups (A: yes and B: no ).
According to the presence of abnormal liver function, patients were divided into two groups (C: yes and D: no). PCT levels
were compared between groups. Results The serum PCT levels were increased at acute phase in 56 (46.67% ) patients
before the treatment than those in normal children, which were decreased obviously after treatment (P＜0.05). There were 31
cases combined with CAL, the rising rate of PCT was 38.71%, which was no significant difference compared with that of 
NCAL group (49.44%, P＞0.05). There was no significant difference in serum PCT value between CAL group and NCAL
group (P＞0.05). The serum C-reactive protein level was significantly higher in CAL group than that of NCAL group. There
were 35 patients combined with gastrointestinal symptoms in 120 KD patients. There was no significant difference in the
rising rate of PCT between patients with gastrointestinal symptoms (62.86%) and patients without gastrointestinal symptoms
(40.00%, P＜0.05). There was no significant difference in serum PCT level between these two groups of patients. There were
42 cases with liver dyfunction in 120 KD patients, the PCT rising rate (52.38%) was no statistically significant difference
compared with that of patients with no liver dyfunction (43.59%, P＞0.05). And there was no significant difference in serum
PCT value between the two groups (P＞0.05). Conclusion PCT can reflect the acute phase of KD patients. The increased
PCT level may be related with the emergence of gastrointestinal symptoms, even though it cannot predict CAL and the
occurrence of liver damage.

Key words: mucocutaneous lymph node syndrome, calcitonin, coronary artery disease, gastrointestinal diseases, liver
diseases, Kawasaki disease, procalcitotin