Abstract: Abstract: Objective To explore the expression of fatty acid-binding protein 5 (FABP5) gene and its prognostic significance in renal clear cell carcinoma. Methods Data of FABP5 were retrieved from Oncomine and GEO database, then the role of FABP5 in renal clear cell carcinoma was mined and analyzed. The DAVID database was used to analyze the function of differentially genes, and the prognosis analysis was analyzed by GEPIA. Results Totally, 445 different types of cancer studies about the expression of FABP5 were identified in the Oncomine database. The FABP5 expression was statistically significant in 63 of the studies, over-expressed in 32 (5 in renal carcinoma) and under-expressed in the other 24 (0 in renal carcinoma). There were 4 studies involved the expression of FABP5 in clear cell renal cell carcinoma and normal tissues. Compared with normal tissues, the expression of FABP5 was higher in renal clear cell carcinoma (P＜0.05). In addition, through further mining the data set GSE66271 of GEO database, the results showed that the expression of FABP5 was higher in renal clear cell carcinoma than that in normal tissue (P＜0.001). The results of GSE66271 microarray data analysis in GEO database showed that the expression of differential gene FABP5 was significantly higher in renal clear cell carcinoma than that of normal tissue (P＜0.01). DAVID functional analysis found that these differential genes mainly focus on the affectting transfer protein activity and protein digestion and absorption metabolic function. The overall mortality was higher in patients with over-expressed FABP5 (n=258), and the prognosis was better in patients with under-expressed FABP5 (n=258) analyzed by GEPIA using TCGA database and GTEx project (P=0.001 1). Conclusion FABP5 is highly expressed in renal clear cell carcinoma, and its expression is associated with poor prognosis of renal clear cell carcinoma, which might be an important therapeutic target of renal clear cell carcinoma.

Key words:  adenocarcinoma, clear cell, automatic data processing, database management systems, FABP5 gene, renal clear cell carcinoma, oncomine database,  GEO database, DAVID database, GEPIA, data mining