Abstract: Insulin resistance (IR) is an important mechanism of type 2 diabetes. It affects the transmission of various
signaling pathways, thereby disrupting glucose metabolism. Signaling and the transcriptional activation factor 3 (STAT3)
pathway are important pathways that regulate gene transcription. There is evidence that STAT3 signaling pathway is a key
factor of IR, which can regulate the mitogen-activated protein kinase (MAPK) pathway, insulin receptor substrate-1 (IRS-1) /phosphatidyl inositol 3 kinase (P13K) / protein kinase B (PKB) pathway and other insulin-related pathways. The STAT3
signaling pathway is activated by the upstream cytokine interleukin-22 (IL-22) and is involved in the regulation of glucose
metabolism. It is a current research hotspot. This article reviews the relationship between the STAT3 pathway and IR to
further clarify the pathogenesis of glucose metabolism.

Key words: diabetes mellitus, type 2, STAT3 signaling pathway, insulin resistance