Abstract: Abstract: Objective To assess therapeutic efficacy and safety of balloon assisted enteroscopy (BAE) for treatment of
Peutz-Jeghers polyps (PJP) with intussusceptions, and to explore the critical factors that affect the choice of treatment for
PJP with intussusception. Methods The clinical data of patients identified as PJP intussusception were collected at the Air
Force Medical Center from January 2013 to June 2019. Forty-eight patients were finally enrolled according to the inclusion
and exclusion criteria. The ration of male to female was 28∶20, and the mean age was (20.6±9.2) years old. The success rate,
the incidence of complications and other clinical data,such as age, gender, history of surgeries, clinical symptoms, diameter
of lead polyps, the number of intussusceptions, and the longest length of single intussusception were analyzed. Case control
study was performed to compare the different indexes between patients in pure enteroscopic treatment group and surgical
treatment group. Results The overall effective rate of BAE treatment of PJP with intussusception was 83.3% (35/42), and
the postoperative complication rate was 2.4% (1/42). Thirty-five patients that were treated successfully by BAE were
classified as the BAE group, and 13 patients treated with surgery were classified as surgery group. There were no statistically
significant differences in gender, history of surgeries, positive rate of PJS family history, average diameter of lead polyps and
number of intraoperative polyps between the two groups. The average age was smaller in BAE group than that in surgery
group. The proportion of patients with no or mild clinical symptoms was higher in the BAE group than that in surgery group.
The number of intussusception was less in the BAE group than that in surgery group, and the longest length of single
intussusception was shorter than that in surgery group (P＜0.05). Conclusion BAE is safe and effective in the management
of PJP with intussusception, which can be used as the first-line treatment for PJP with intussusception coinciding incomplete
intestinal obstruction.

Key words: Peutz-Jeghers syndrome, intestinal polyps, intussusception, balloon-assisted enteroscopy