Tianjin Medical Journal

Tianjin Medical Journal ›› 2020, Vol. 48 ›› Issue (12): 1180-1184.doi: 10.11958/20201663

• Clinical Study • Previous Articles     Next Articles

The predictive value of preoperative nutritional status score for postoperative PSA #br# progression in patients with oligometastatic prostate cancer#br#

WANG Wei1, HUA Li-xin2, DING Liang1△, LI Peng-chao2   

  1. 1 Department of Urology, Pukou Branch of Jiangsu Provincial People’s Hospital, Nanjing 211800, China; 
    2 Department of Urology, Jiangsu Provincial People’s Hospital
  • Received:2020-06-13 Revised:2020-09-11 Published:2020-12-15 Online:2020-12-13
  • Contact: ING Liang E-mail:dingliang008@21cn.com

PDF (PC)

5802

Abstract: Objective　To investigate the clinical value of preoperative controlling nutritional status (CONUT) score in postoperative prostate specific antigen (PSA) progression in patients with oligometastatic prostate cancer (OPC). Methods　From January 1, 2016 to December 31, 2018, 102 patients with OPC who underwent laparoscopic radical prostatectomy in our hospital were included. Serum albumin concentration, peripheral blood lymphocyte count and total cholesterol concentration were measured 3 days before operation, and CONUT score was calculated. The data of body mass index (BMI), PSA level, T stage, N stage, positive margin and ADT were collected. Receiver operating characteristic (ROC) curve was drawn to determine the cut-off value of CONUT in predicting PSA progression. The differences of clinical characteristics in patients with different CONUT scores were analyzed. Cox regression was used to analyze the factors influencing PSA progression. Kaplan-Meier method was used to draw survival curve and analyze the relationship between CONUT score and PSA progress. Prostate specific antigen progression-free survival (PSA-PFS) was calculated. Results　 Until December 31, 2019, 62 of 102 patients showed PSA progression. The cut-off value of CONUT score in predicting the progression of PSA in OPC patients was 3 points. There were significant differences in Gleason score, T stage and positive margin between low CONUT group (＜ 3 points, 50 cases) and high CONUT group (≥ 3 points, 52 cases, all P＜0.01). Cox regression analysis showed that CONUT score ≥ 3 was an independent risk factor for the prognosis of patients with OPC (HR = 2.982, 95%CI: 1.706-5.213, P＜0.01). The survival analysis showed that PSA-PFS was significantly shorter in high CONUT group than that in low CONUT group (P＜0.01). Conclusion　CONUT score can be an effective predictor for PSA progression in patients with OPC, and ≥ 3 points indicate the risk of PSA progression.

Key words: prostatic neoplasms, prostate-specific antigen, oligometastasis, controlling nutritional status score

CLC Number: