Abstract: Objective To investigate the predictive value of triacylglycerol high-density lipoprotein cholesterol ratio (TG/HDL-C) and triacylglycerol glucose product index (TyG) on the development of hyperuricemia (HUA) in patients with type 2 diabetes mellitus (T2DM). Methods A total of 668 patients diagnosed with T2DM were selected and were divided into HUA group (n=183) and non-hyperuricemia (NUA) group (n=485) according to their serum uric acid levels. The basic information, physical examination and other data of patients were collected. The laboratory-related indicators were tested. Multivariate Logistic regression was used to explore the relationship of TG/HDL-C (quartiles Q1 to Q4 groups) and TyG index (quartiles q1 to q4 groups) with the development of HUA in patients with T2DM, and the effect of both with serum uric acid on diabetic complications. The subject working characteristic (ROC) curve was used to assess the predictive value of the TG/HDL-C and TyG index for HUA in T2DM patients. Results Multivariate Logistic regression analysis showed that after uncontrolled and controlled for age, sex, systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass, body mass index (BMI), waist circumference (WC) and hip circumference, the risk of HUA was higher in quartiles 3 and 4 groups of the TG/HDL-C and TyG index than that in quartile 1 group (P < 0.05), and there was no significant difference between quartile 2 group and quartile 1 group (P＞0.05). After further control of triacylglycerol (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDLC), history of hypertension, history of smoking, and history of alcohol consumption, the risk of HUA was still higher in quartiles 3 and 4 groups of TG/HDL-C than that in quartile 1 group (P < 0.05), while TyG index was not associated with the risk of HUA at this time (P＞0.05). TG/HDL-C, TyG index and serum uric acid were three risk factors for diabetic albuminuria, and TG/HDL-C was a protective factor for diabetic peripheral neuropathy (P＜0.05), while all three were not associated with diabetic retinopathy (P＞0.05). The area under the ROC curve showed that TG/HDL-C and TyG index were both predictive for HUA, and the AUC of TG/HDL-C was 0.651, the AUC of TyG index was 0.617. Conclusion TG/HDL-C and TyG index are risk factors for the occurrence of HUA in T2DM, and both have some predictive value for HUA. TG/HDL-C, TyG index and serum uric acid are closely related to diabetic complications and should be closely monitored clinically.

Key words: diabetes mellitus, type 2, hyperuricemia, triglyceride-to-high density lipoprotein cholesterol ratio, triglyceride-glucose index, predictive value