Abstract: Objective　To compare and analyze the clinical efficacy and safety of artificial liver support system (ALSS) and glucocorticoid in the treatment of severe acute drug-induced liver injury. Methods　The clinical data of 120 patients with severe acute drug-induced liver injury were retrospectively analyzed. These patients were divided into ALSS group and glucocorticoid group according to different treatment methods, with 60 cases in each group. The liver function and adverse reactions were compared before and after treatment between the two groups. Results　The clinical symptoms were significantly improved after treatment in the two groups of patients. Compared with before treatment, the serum alanine transferase (ALT), aspartic acid transferase (AST), total bile acid (TBA) and total bilirubin (TBIL) were significantly reduced after treatment in the two groups (P＜0.05), and the prothrombin activity (PTA) was significantly increased (P＜0.05). The clinical effect of the ALSS group was more significant than that of the glucocorticoid group (P＜0.05). The total effective rate of the ALSS group was significantly higher than that of the glucocorticoid group (χ2=5.175, P＜0.05). There were no serious adverse reactions in the two groups, and the safety of these two methods were good. Conclusion　Both ALSS treatment and glucocorticoid treatment can effectively improve the clinical symptoms and liver function of severe acute liver damage. ALSS treatment is superior to glucocorticoids in effective time and efficiency in the treatment of patients with severe acute drug-induced liver damage, and has higher safety.

Key words: liver, artificial, glucocorticoids, chemical and drug induced liver injury, severe acute drug-induced liver injury