The diagnostic values of WMR, MLR and their combination in the severity of coronary artery disease

doi:10.11958/20220181

Abstract

Abstract:

Objective To explore the association of the number of white blood cell to mean platelet volume ratio (WMR), monocyte to lymphocyte ratio (MLR) and their combination on the diagnostic value for coronary artery disease (CAD) and the severity of coronary artery stenosis. Methods A total of 2 728 inpatients were divided into the CAD group (n=1 884) and the non-CAD group (n=844) according to coronary angiography (CAG)．The clinical and laboratory data of all the subjects were collected. The cutoff values of these inflammatory markers to diagnose CAD were calculated using receiver operating characteristic (ROC) curves. Multivariate Logistic regression model for the risk factors of CAD was established. The correlation between WMR, MLR and the severity of CAD was analyzed. Results The proportion of male, age≥65 years, smoking, hypertension, diabetes, dyslipidemia, ischemic stroke, WMR≥0.77 and MLR≥0.27 levels were significantly higher in the CAD group than those in the non-CAD group (P<0.05). The areas under the ROC curves of the WMR, MLR and WMR+MLR were 0.639 (95%CI: 0.618-0.661), 0.621 (95%CI: 0.598-0.644) and 0.677 (95%CI: 0.656-0.698), respectively (P<0.05). The elevated WMR and MLR were independent risk factors for CAD (P<0.05). WMR and MLR were positively correlated with Gensini score (P<0.05). Conclusion The combined elevation of WMR and MLR is an independent risk factor for CAD, which is expected to be a novel inflammatory marker to help diagnose CAD.

Key words: coronary disease, early diagnosis, risk factors, white cell count to mean platelet volume ratio, monocyte count to lymphocyte count ratio

CLC Number:

R541.4

Figures/Tables 4

References 24

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