Abstract:

Objective To observe the effect of oral glucocorticoid combined with ocular hypotensive drugs on the development of myopia in patients with pathologic myopia (PM) complicated with multifocal choroiditis (MFC). Methods A total of 56 PM patients (76 eyes) with MFC were collected, and they were treated with moderate-dose glucocorticoid (prednisone acetate) orally, with an average course of 13.5 weeks. At the same time, they were combined with brinzolamide eye drops for 24 months. Axial length (AL), spherical equivalent (SE), intraocular pressure, best corrected visual acuity (BCVA) and mean sensitivity of visual field ( mean sensitivity, MS) were followed-up and recorded at 3 months, 6 months, 12 months, 18 months and 24 months. Results After treatment, the color image of the fundus showed that the lesion area was slightly smaller than that before treatment, and the leakage of FFA fluorescein was improved compared with that before treatment. Compared with before treatment, there were no significant differences in AL, SE and intraocular pressure only at 3 months after treatment, and there were no significant differences in AL and SE at 24 months after treatment. Compared with before treatment and 3 months after treatment, there were significant differences in each index at 6, 12 and 18 months after treatment (P<0.05). There were significant differences in BCVA and visual field MS at different time points between 3, 6 and 24 months after treatment (P<0.05). At 3 and 24 months after treatment, there was no correlation between AL and intraocular pressure and SE. At 6, 12 and 18 months after treatment, AL was positively correlated with intraocular pressure and negatively correlated with SE (P<0.01). Conclusion Oral glucocorticoid combined with ocular hypotensive drugs to treat PM with MFC can control the growth of PM AL and myopia diopter, and effectively improve visual function.

Key words: myopia, degenerative, glucocorticoids, clinical protocols, multifocal choroiditis