A clinical study on type A botulinum toxin combined with red and blue light therapy in improving facial post-traumatic pigmentation

doi:10.11958/20253270

Abstract

Abstract:

Objective To explore the clinical effect of botulinum toxin type A combined with red and blue light in improving post-traumatic facial pigmentation. Methods A total of 120 patients with post-traumatic facial pigmentation were selected as the research subjects and randomly divided into the red and blue light group (60 cases) and the combined treatment group (60 cases) according to the random number table method. The red and blue light group was treated with a red and blue light therapy device for 6 weeks, and the combined treatment group was given botulinum toxin type A injection on the basis of the red and blue light group. The therapeutic effects, skin property scores before and after treatment, facial image scores, changes in serum oxidative stress indicators such as malondialdehyde (MDA), lipid peroxides (LPO) and superoxide dismutase (SOD), as well as the occurrence of adverse reactions were compared between the two groups. Results The total effective rate was significantly higher in the combined treatment group than that of the red and blue light group (78.33% vs. 60.00%, P<0.05). After treatment, the skin moisture, elasticity scores, pigmentation scores and serum SOD levels were increased in both groups, and those in the combined treatment group were higher than those in the red and blue light group (P<0.05). After treatment, the serum MDA, LPO levels and pigmentation area scores were decreased in both groups, and those in the combined treatment group were lower than those in the red and blue light group (P<0.05). There was no statistically significant difference in the total incidence of adverse reactions between the red and blue light group and the combined treatment group (20.00% vs. 16.67%, P > 0.05). Conclusion Botulinum toxin type A combined with red and blue light therapy has a good clinical efficacy and high safety in the treatment of post-traumatic facial pigmentation.

Key words: pigmentation, external injury, botulinum toxins, type A, superoxide dismutase, red and blue light, facial image scores

CLC Number:

R751.05

Figures/Tables 7

References 27

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组别		性别				年龄/岁
组别		男		女		年龄/岁
红蓝光组		25（41.67）		35（58.33）		32.34±4.21
联合治疗组		21（35.00）		39（65.00）		33.75±4.16
t或χ²		0.564				1.845
组别	病程/月		色素沉着程度
组别	病程/月		轻度		中度		重度
红蓝光组	3.86±0.92		17（28.33）		29（48.33）		14（23.33）
联合治疗组	4.21±1.05		19（31.67）		26（43.33）		15（25.00）
t或χ²	1.387		0.309

组别		性别				年龄/岁
组别		男		女		年龄/岁
红蓝光组		25（41.67）		35（58.33）		32.34±4.21
联合治疗组		21（35.00）		39（65.00）		33.75±4.16
t或χ²		0.564				1.845
组别	病程/月		色素沉着程度
组别	病程/月		轻度		中度		重度
红蓝光组	3.86±0.92		17（28.33）		29（48.33）		14（23.33）
联合治疗组	4.21±1.05		19（31.67）		26（43.33）		15（25.00）
t或χ²	1.387		0.309

组别	痊愈	显效	好转	无效	总有效
红蓝光组	14（23.33）	22（36.67）	15（25.00）	9（15.00）	36（60.00）
联合治疗组	20（33.33）	27（45.00）	11（18.33）	2（3.33）	47（78.33）
χ²					4.728^＊

组别	痊愈	显效	好转	无效	总有效
红蓝光组	14（23.33）	22（36.67）	15（25.00）	9（15.00）	36（60.00）
联合治疗组	20（33.33）	27（45.00）	11（18.33）	2（3.33）	47（78.33）
χ²					4.728^＊

组别	水分
组别	治疗前	治疗后	t
红蓝光组	41.26±5.03	74.26±7.61	28.818^＊＊
联合治疗组	42.13±5.11	87.54±8.92	37.307^＊＊
t	0.940	8.773^＊＊
组别	弹性
组别	治疗前	治疗后	t
红蓝光组	10.12±1.03	14.34±1.52	16.831^＊＊
联合治疗组	10.25±1.06	17.45±1.83	26.486^＊＊
t	0.681	10.126^＊＊