Abstract: [Abstract]　Objective: To discuss the surgical method and clinical effect of endoscopic transnasal approach and neuronavigation to resect chordomas of skull base. Methods: Twenty-five cases of chordomas operated via transsphenoidal sinus approach were retrospectively analyzed. Results: Tumor was totally removed in 9 patients, subtotally in 13, and partially in 3. Clinical symptoms of 20 patients were relieved after operation, and not relief in 5. There was no operative death or any postoperative complications. During the follow-up periods, tumor recurred in about 12 months after operation in 1 cases only got partial resection of the tumor, and recurred 3 years after operation which metastasized to the distal organs in 1. Conclusion: Endoscopic transnasal approach and neuronavigation is adapted to resect chordomas of saddle area or middle and upper clivus and those lesions involving nasal cavity, nasal sinuses and nasopharynx. Endoscopic transnasal approach and neuronavigation has many advantages, such as safety, efficiency, minimal invasion, simple manipulation, timesaving, good results.

Key words: chordomas, endoscopic surgery, neuronavigation, transsphenoidal approach