Abstract: [ Abstract ] Objective : To find out the difference of the enzyme in serum between the severe case and mild case with H1N1 influenza and between the groups at different time points, to understand its clinical significance, and infer possible reasons. Methods :We selected H1N1 influenza in patients with severe and mild respectively 10 cases who admitted to hospital the first day, the third day and the seventh day of alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), serum creatine kinase (CK) and creatine kinase isoenzyme (CK-MB) of all values between the two groups, and severe group and mild group comparisons between different time points. Results : There were significant difference (p <0.05) between severe group and mild group in ALT, AST, LDH, CK-MB at all time points. There was significant difference between severe group and mild group in CK at the admission day ,but no significant difference between the two groups in CK at the the third day and the seventh day. There was significant difference between the admission day and the third, the seventh day respectively in CK in severe group. There was no statistical difference among different time points in severe group in ALT, AST, LDH, CK-MB. There was no statistical difference among different time points in mild group. Conclusion : The enzyme in severe group patients with H1N1 influenza was significantly higher than those in mild patients, suggesting the liver and myocardial damaged in severe patients . The mechanism of liver and myocardial damage in severe patients would need further study .The enzyme between two groups at different time points changed little in one week after hospitalization. [ Key words] type A(H1N1) influenza; aminotransferase; myocardial enzyme

Key words: type A(H1N1) influenza, aminotransferase, myocardial enzyme