Abstract: Abstract Objective:To study the correlation between serum leptin (LEP) level and urine micro-albumin in patients with simple obesity,discuss the effects of leptin on kidneys . Methods:60 patients with simple obesity and 40 controls in this study. Height,body weight,waist circumference,hip circumference,systolic blood pressure, diastolic blood pressure,blood glucose, total cholesterol, triglyceride,blood urea nitrogen,serum creatinine, uric acid ,urine micro-albumin, urine creatinine as well as serum leptin were observed in each group and compared. Meanwhile, body mass index(BMI) , waist-hip ratio(WHR) ,mean arterial pressure(MAP) and the ratio of urine micro-albumin and urine creatinine(UACR) were counted. Results: In compare with control group,serum LEP and UACR in obese group were significantly increased(P<0.01). Serum LEP in obese group was in a positive correlation with BMI (r =0.650,P<0.001),WHR (r =0.617,P<0.001) and blood glucose (r =0.345,P<0.05),but had not significant correlation with UACR(r = -0.146,P>0.05). Conclusion: The level of serum LEP and UACR are related to obesity.But there is not significant correlation between serum LEP and UACR.

Key words: simple obesity, body mass index, serum leptin, the ratio of urine micro-albumin and urine creatinine, kidney injury