Abstract: Abstract Objective：To investigate the expression and significance of FHIT and it’s relationship with Survivin in sinonasal inverted papilloma (SNIP) . Method：Immunohistochemical method was used to determine the expression of FHITand Survivin in 50 cases of SNIP,20 cases of sinonasal squamous cell carcinoma (SCC) and 20 cases of normal sinonasal tissues,to analyse the result depending on clinical stages and recurrence . Results：(1)FHIT was expressed in 15 of 50 (30%) cases of SNIP,the diffences with normal sinonasal tissues have statistic significance(P <0.01) , the diffences with SCC have not statistic significance(P>0.05), and the expression is not relative to the clinical stages and the age. (2) Survivin was expressed in 40 of 50(80%) cases of SNIP, the diffences with normal sinonasal tissues have statistic significance(P<0.01) , he diffences with SCC have not statistic significance(P>0.05) ,and the expression are increasing with the clinical stages and the age. (3) The inactivation of FHIT and the activation of Survivin in SNIP are distinct correlation(P<0.01). Conclusion：The inactivation of FHIT and the activation of Survivin may play an important role in the pathway of progression of SNIP and SCC. They may be identified as a new therapeutic target .

Key words: Sinonasal inverted papilloma, Sinonasal carcinoma, FHIT, Survivin, Immunohistochemical