Abstract: Objective: To observe the relationship of carotid plaque with serum bilirubin and uric acid in patients of coronary heart disease(CHD). Methods: One hundred and eighty-four patients with CHD were enrolled in our study. All patients were examined for carotid intima-media thickness (IMT) by carotid artery ultrasound technology. According to the IMT, we divided the subjects into plaque group including eighty-two cases(IMT≥1.3mm) and non-plaque group including one hundred and two cases(IMT<1.3mm). The general conditions including age, sex, history of hypertension , smoking ,etal and laboratory parameters including the levels of total serum bilirubin, direct bilirubin, indirect bilirubin , uric acid, etal were recorded. All clinical data were statistically analyzed and processed. Results: The levels of total bilirubin and indirect bilirubin were lower in plaque group patients than those in non-plaque group patients, while the levels of uric acid were higher in plaque group patients than those in non-plaque group patients. All of these differences had statistical significance (P<0.05), Pearson correlation analysis indicated that the level of total bilirubin and indirect bilirubin negatively and the level of uric acid positively related with carotid plaque, the result of logistic step regression analysis showed that indirect bilirubin and uric acid were the independent risk factors of carotid plaque. Conclusion: Carotid atherosclerosis associated with abnormal serum bilirubin and uric acid in CHD patients. Interfering with the generation of bilirubin and uric acid may prevent cardiocerebrovascular incidents in CHD patients.

Key words: coronary heart disease, carotid plaque, total bilirubin, indirect bilirubin, uric acid